Citation: Wei Jin, Wei-Yu Wang, Yu-Lian Zhang, Yong-Jian Yang, Qing-Cui Chu, Jian-Nong Ye. Determination of phenolic whitening agents in cosmetics by micellar electrokinetic capillary chromatography with amperometric detection[J]. Chinese Chemical Letters, ;2013, 24(07): 636-638. shu

Determination of phenolic whitening agents in cosmetics by micellar electrokinetic capillary chromatography with amperometric detection

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a Department of Chemistry, East China Normal University, Shanghai 200241, China;
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b Shanghai Institute for Food and Drug Control, Shanghai 201203, China

Corresponding author: Qing-Cui Chu, Jian-Nong Ye,
Received Date: 17 January 2013
Available Online: 21 March 2013

A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar electrokinetic capillary chromatography with amperometric detection (MECC-AD). Effects of several factors, such as the pH value and concentration of running buffer, potential applied to the working electrode, separation voltage, and injection time were investigated to obtain optimum conditions for separation and detection. With a 75 cm long fused-silica capillary tube, well-defined separation of six phenolic compounds was achieved in 10 mmol/L SDS/40 mmol/L H₃BO₃-Na₂B₄O₇ running buffer (pH 9.0). Good linear relationship was obtained for each analyte over three orders of magnitude with correlation coefficients (r²) between 0.9985 and 0.9994, and the detection limit (S/N=3) ranged from 0.04 μg/mL to 0.45 μg/mL. The proposed method has been successfully applied for the determination of phenolic whitening agents in real cosmetic samples with satisfactory results, providing an alternative monitoring method for cosmetics safety regulation.
- Micellar electrokinetic capillary,
- chromatography,
- Amperometric detection,
- Phenolic whitening agents,
- Cosmetics
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沈阳化工大学材料科学与工程学院沈阳 110142