Citation: Shahnaz Rostamizadeh, Masoomeh Nojavan, Reza Aryan, Hamid Sadeghian, Mahdieh Davoodnejad. A novel and efficient synthesis of pyrazolo[3, 4-d]pyrimidine derivatives and the study of their anti-bacterial activity[J]. Chinese Chemical Letters, ;2013, 24(07): 629-632. shu

A novel and efficient synthesis of pyrazolo[3, 4-d]pyrimidine derivatives and the study of their anti-bacterial activity

a Department of Chemistry, Faculty of Science, K.
a Department of Chemistry, Faculty of Science, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran;
2.
b Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran;
3.
c Resistance Research Center, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad 91967-73117, Iran;
4.
d Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad 91857-63788, Iran

Corresponding author: Shahnaz Rostamizadeh,
Received Date: 20 February 2013
Available Online: 11 April 2013

In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot, three-component reaction of an aldehyde, malononitrile and benzamidine hydrochloride, in the presence of magnetic nano Fe₃O₄ particles as a catalyst under solvent-free conditions. 3-Amino-6-aryl-2-phenylpyrazolo[3,4-d]pyrimidine derivatives were prepared through an efficient and environmentally friendly reaction between 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives and hydrazine hydrate and their antibacterial activity has been evaluated.
- Pyrazolo[3,4-d]pyrimidine derivatives,
- Pyrimidine-5-carbonitrile derivatives,
- Antibacterial activity,
- Staphylococcus aureus,
- Enterococcus raffinosus
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