Citation: Sunil Vodela, Raghu Vardhan Reddy Mekala, Ravinder Reddy Danda, Venkateshwarlu Kodhati. Design, synthesis and screening of some novel benzoxazole based 1, 3, 4-oxadiazoles as potential antimicrobial agents[J]. Chinese Chemical Letters, ;2013, 24(07): 625-628. shu

Design, synthesis and screening of some novel benzoxazole based 1, 3, 4-oxadiazoles as potential antimicrobial agents

1.
a Talla Padmavathi College of Engineering, Somidi, Kazipet 506003, Andhra Pradesh, India;
2.
b Department of Chemistry, Kakatiya University, Warangal 506009, Andhra Pradesh, India;
3.
c Department of Chemistry, Mahathma Gandhi University, Nalgonda 508254, Andhra Pradesh, India;
4.
d Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda 506001, Andhra Pradesh, India

Corresponding author: Raghu Vardhan Reddy Mekala,
Received Date: 15 January 2013
Available Online: 26 March 2013

A series of novel 2-(5-substituted-[1,3,4]oxadiazol-2-yl)-benzoxazoles (7a-h) were synthesized in good yields in two different directions by involving benzoxazole-2-carboxylic acid (1) as raw material and benzoxazole-2-carbonyl chloride (2), benzoxazole-2-carboxylic acid methyl ester (3), benzoxazole-2-carboxylic acid hydrazide (4), benzoxazole-2-carboxylic acid N'-acetyl hydrazide (5a-d) and benzoxazole-2-carboxylic acid-ethylidene-hydrazides (6a-d) as reactive intermediates. The chemical structures of all the synthesized compounds were elucidated by their IR, ¹H NMR and ¹³C NMR and mass spectral data. Further, the target compounds were screened for their antimicrobial activity against various Gram-positive and Gram-negative bacteria.
- Benzoxazoles,
- 1,3,4-Oxadiazoles,
- Antimicrobial activity
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