Citation: Santosh V. Goswami, Prashant. B. Thorat, Vijay N. Kadam, Sachin A. Khiste, Sudhakar R. Bhusare. A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid[J]. Chinese Chemical Letters, ;2013, 24(05): 422-424. shu

A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

1.
Department of Chemistry, Dnyanopasak College, Parbhani 431 401, MS, India

Corresponding author: Sudhakar R. Bhusare,
Received Date: 24 January 2013
Available Online: 4 March 2013

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3-chlorophenylboronic acid as a catalyst under ambient temperature conditions. The three-component reaction of indoles, aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields. This protocol presents some remarkable features such as mild reaction conditions, simple workup procedure and excellent yields.
- 3-Aminoalkylaed indoles,
- 3-Chlorophenylboronic acid,
- Aromatic aldehyde,
- N-Methylaniline,
- Indoles
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沈阳化工大学材料科学与工程学院沈阳 110142