Citation: Ming-Dong Lu, Xiao Zhou, Yao-Jun Yu, Pi-Hong Li, Wei-Jian Sun, Cheng-Guang Zhao, Zhi-Qiang Zheng, Tao You, Fei-Hai Wang. Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents[J]. Chinese Chemical Letters, ;2013, 24(05): 415-418. shu

Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents

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a Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325035, China;
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b Department of Gynaecology and Obstetrics, The Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325035, China;
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c School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China

Corresponding author: Zhi-Qiang Zheng,
Received Date: 25 December 2012
Available Online: 26 January 2013

Novel furoxan-based nitric oxide-releasing derivatives 6a-p of hydroxylcinnamic acids were synthesized by coupling the carboxyl group of hydroxylcinnamic acids with furoxan through various alkylol amines. Compounds 6a, e-i and m-p displayed more potent anti-tumor activities superior to control 5-fluorouracil (5-FU) in most cancer cells tested. Furthermore, 6f could selectively inhibit tumor cells, but not non-tumor cell proliferation. This inhibition was attributed to high levels of NO released in cancer cells and potentially synergistic effect of NO donor moieties and the bioactivity of hydroxylcinnamic acids.
- Synthesis,
- Hydroxylcinnamic acids,
- Furoxans NO donor,
- Anti-tumor agents,
- Cytotoxic activities
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沈阳化工大学材料科学与工程学院沈阳 110142