Citation: Ting Ai, Shao-Yu Shi, Li-Ting Chen, Ling Li, Bo Cao, Ying Gao, Hong Chen, Jing Zhou. Synthesis and anti-tumor activity evaluation of novel podophyllotoxin derivatives[J]. Chinese Chemical Letters, ;2013, 24(01): 37-40. shu

Synthesis and anti-tumor activity evaluation of novel podophyllotoxin derivatives

Ting Ai ^a,b ,
Shao-Yu Shi ^a,b ,
Li-Ting Chen ^a ,
Ling Li ^b ,
Bo Cao ^b ,
Ying Gao ^b ,
Hong Chen ^a,b,, ,
Jing Zhou ^a,,

1.
a Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China;
2.
b Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Department of Pharmacognosy, Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China

Corresponding author: Hong Chen, Jing Zhou,
Received Date: 25 September 2012
Available Online: 13 November 2012

In order to investigate the effects on the cytotoxicity of indole-3-oxalylamino podophyllotoxin analogs, seven novel podophyllotoxin derivatives were synthesized.The compounds were tested against Hela, K562 or K562/A02 cancer cells in vitro,four of which showed significant cytotoxicity.Among them 9a,9b and 9c were superior to the positive control VP-16.
- Podophyllotoxin,
- C4-N-substitution,
- Indole,
- Cytotoxicity
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