Citation: Zhi-Gang Luo, Zheng-Yong Liu, Zhuo-Hong Yang. The synthesis and photoactivated cytotoxicity of novel 5-phenyl-3- (2, 2':5', 2''-terthien-5-yl)-4, 5-dihydro-1H-pyrazolines[J]. Chinese Chemical Letters, ;2014, 25(2): 333-336. shu

The synthesis and photoactivated cytotoxicity of novel 5-phenyl-3- (2, 2':5', 2''-terthien-5-yl)-4, 5-dihydro-1H-pyrazolines

1.
Institute of Biomaterial, College of Sciences, South China Agricultural University, Guangzhou 510642, China

Corresponding author: Zhuo-Hong Yang,
Received Date: 16 July 2013
Available Online: 23 October 2013
Fund Project: The authors are thankful for partial financial support by Guangdong Natural Science Foundation (No. 7006672) (No. 7006672)South China Agricultural University Foundation (Nos. 2009B010100001, 2009C020604002). (Nos. 2009B010100001, 2009C020604002)

A series of novel 5-phenyl-3-(2,2':5',2''-terthien-5-yl)-4,5-dihydro-1H-pyrazolines were synthesized in this report. Their photoactivated cytotoxicities on the Spodoptera litura (SL) cell line were evaluated using the MTT method. It was noticed that the inhibitory activities of all the conjugates was enhanced when irradiated with UV-A light. Compounds 4, 6 and 8 were found to be most effective with inhibition rates of 88.1%, 88.0%, and 90.5%, respectively. For compound 5, the inhibition rate value was only slightly enhanced under the irradiation treatment (78.3%) compared to the dark treatment (74.8%). The relationship analysis between structure and activity showed that the middle thiophene ring played an important role on the inhibitory activities. It was shown that these compounds could be the potential candidates for new photoactivated pesticides.
- Terthienyl,
- Pyrazolines,
- Hotoactivated cytotoxicity,
- Spodoptera litura cell
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沈阳化工大学材料科学与工程学院沈阳 110142