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Citation: Jian SONG, Xiao Lei WANG, Yue Jun XIANG, Chung K. CHU, Raymond SCHINAZI, Kang ZHAO. Synthesis of β-L-2', 3'-Dideoxy-2'-fluoro-3'-hydroxy-methylarabinofuranosyl Pyrimidine Nucleosides[J]. Chinese Chemical Letters, ;2004, 15(2): 135-137. shu

Synthesis of β-L-2', 3'-Dideoxy-2'-fluoro-3'-hydroxy-methylarabinofuranosyl Pyrimidine Nucleosides

1.
The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072;
2.
Department of Chemistry, New York University, New York, NY 10003;
3.
Department of Medicinal Chemistry, College of Pharmacy, The University of Georgia, Athens, GA 30602;
4.
Center for AIDS research/Veterans Affairs Medical Center, Decatur, GA 30033;and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322

Received Date: 16 January 2003

Fund Project: We thank the supports from the National Young Scholar Award of the NNSFC (#30125043) and from the Chung Kong Scholars Program administered by the Ministry of Education, PRC and the Li Ka Shing Foundation, Hong Kong. RFS is supported by NIH grant 1R37-AI-41980 and the Department of Veterans Affairs.

β-2', 3'-Dideoxy-2'-fluoro-3'-hydroxymethylarabinofuranosylthymine 10 and cytosine 12 were synthesized from L-xylose and were found to be inactive against HIV-1 in acutely infected lymphocytes.
- L-Nucleoside,
- anti-HIV,
- L-xylose,
- synthesis
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1.
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