Citation: Cheng Ye YUAN, Shu Sen LI, Guo Quan WANG, Hao WU. A CONVENIENT ASYMMETRIC SYNTHESIS OF 1-AMINOALKYLPHOSPHONIC ACIDS[J]. Chinese Chemical Letters, ;1993, 4(9): 753-756. shu

A CONVENIENT ASYMMETRIC SYNTHESIS OF 1-AMINOALKYLPHOSPHONIC ACIDS

Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai 200032

Received Date: 29 April 1993

Fund Project: This project was supported by the National Natural Science Foundation of China.

A convenient method for the asymmetric synthesis of 1-aminoalkylphosphonic acids was described.It involved the diastereoselctive alkylation of bicyclic chloromethylphosphonamide derived from (S)-2-ani-linomethylpyrrolidine followed by subsequent conversions leading to amino compounds by Staudinger method.Acid hydrolysis afforded the target molecule in good yield.
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