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Citation: Yu ZHAO, Peng WANG, Xiao Jiang HAO, Simon PARSONS, David W. H. RANKIN, Hao SHI, Hong YU, Thierry SEVÉNET, Françoise GUÉRITTE. Enantiomeric Sesquiterpene Lactones from Senecio tsoongianus[J]. Chinese Chemical Letters, ;2002, 13(8): 754-757. shu

Enantiomeric Sesquiterpene Lactones from Senecio tsoongianus

1.
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;
2.
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204;
3.
Department of Chemistry, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, U.K.;
4.
Inmore Laboratory of Biotechnology, Kunming 650011;
5.
Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France

Received Date: 15 November 2001

Fund Project: This work is financially supported in part by the Life Sciences Special Fund of Chinese Academy of Sciences Supported by the Ministry of Finance (STZ-00-24), the Yunnan Province Foundation of Applied Basic Research (2000C0072M), the Chine-France PRA (grant No.PRA BT01-02), and EGIDE Foundation (France). Y. Zhao also would like to express his thankfulness to Chinese Ministry of Education and Mr. Ka-Ching Lee for "Cheung Kong Scholar Chief Professorship" at Zhejiang University.

From Senecio tsoongianus, two pairs of enantiomeric isomers, tsoongianolides A (1) and B (2), tsoongianolides C (3) and D (4) were isolated. Their structures were elucidated by 1D and 2D-NMR techniques and X-ray diffractions. The cytotoxicity to KB cell of 1 and 2 is also reported.
- Sesquiterpenes,
- eremophilanes,
- X-ray,
- cytotoxicity
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