Citation: . SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo[J]. Chinese Journal of Polymer Science, ;2009, 27(2): 231-239. shu

SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo

Received Date: 17 December 2007
Revised Date: 29 January 2008

Polysaccharide coated PLA nanoparticles bearing aldehyde groups were prepared by dialysis of DMSO solution of cholesterol hydrophobic-modified dextran polyaldehyde and PLA against water. The average diameter of the nanoparticles was about 160 nm, and the size distribution was nearly homogenous. The nanoparticles were functionalized simultaneously with CD71 and EGFR antibody through the Schiff’s base reaction, and then radiolabeled with 99mTc. After perfused the radiolabeled nanoparticles into tumor-bearing rats through left common carotid artery, the radioactivity in liver, spleen, kidney and brain was measured by scintillation counter. The results showed that less than 2% of nanoparticles were uptaken by the brain due to the uptake of the nanoparticles by the RES system. However, the coupling of transferrin antibody on the nanoparticles facilitated the penetration of nanoparticles across the blood brain barrier, and more specially, compared with monofuctionalized and native nanoparticles, the multifunctionalization enhanced the tumor accumulation of the nanoparticles in vivo.
1. [1]
  Jialin Guo , Mingrui Gu , Yahui Chen , Tao Xiong , Yiyang Zhang , Simin Chen , Mingle Li , Xiaoqiang Chen , Xiaojun Peng . Nucleic acid delivery by lipid nanoparticles for organ targeting. Chinese Chemical Letters, 2025, 36(11): 110849-. doi: 10.1016/j.cclet.2025.110849
2. [2]
  Weijian Zhang , Xianyu Deng , Liying Wang , Jian Wang , Xiuting Guo , Lianggui Huang , Xinyi Wang , Jun Wu , Linjia Jiang . Poly(ferulic acid) nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages. Chinese Chemical Letters, 2024, 35(9): 109422-. doi: 10.1016/j.cclet.2023.109422
3. [3]
  Yeling Yuan , Lihua Du , Kejing Zeng , Yilu Zheng , Huaping Huang , Yu Shao , Wenqing Wang , Leping Yan , Jun Wu , Changhua Zhang , Hongman Xue , Haozhe He . Hyaluronic acid-modified MOF nanoparticles for encapsulating asparaginase in T-cell acute lymphoblastic leukemia treatment. Chinese Chemical Letters, 2026, 37(1): 111222-. doi: 10.1016/j.cclet.2025.111222
4. [4]
  Xin-Yu Liu , He-Ying Mao , Jun-Sheng Hu , Tong-Rui Dou , Ben-Chi Liu , Chang-Xiu Lin , Jing-Shu Piao , Ming-Guan Piao . A c(RGDyK)-modified ROS-responsive polymeric micelle for hepatic stellate cell targeting. Chinese Chemical Letters, 2026, 37(1): 111237-. doi: 10.1016/j.cclet.2025.111237
5. [5]
  Yiyang Zhang , Guangshu Yuan , Xiangkun Meng , Xu Zhang , Lei Yu . Promoting the catalytic activities of polyanilines for L-lactic acid condensation by calcium-doping: A biocompatible strategy. Chinese Chemical Letters, 2025, 36(12): 111069-. doi: 10.1016/j.cclet.2025.111069
6. [6]
  Zhen Liu , Zhi-Yuan Ren , Chen Yang , Xiangyi Shao , Li Chen , Xin Li . Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C₆F₅)₃/chiral phosphoric acid. Chinese Chemical Letters, 2024, 35(5): 108939-. doi: 10.1016/j.cclet.2023.108939
7. [7]
  Liqing Chen , Zheming Zhang , Yanhong Liu , Chenfei Liu , Congcong Xiao , Liming Gong , Mingji Jin , Zhonggao Gao , Wei Huang . Systemically intravenous siRNA delivery into brain with a targeting and efficient polypeptide carrier and its evaluation on anti-glioma efficacy. Chinese Chemical Letters, 2025, 36(3): 110228-. doi: 10.1016/j.cclet.2024.110228
8. [8]
  Xinran Xi , Xiyu Wang , Ziyue Xi , Chuanyong Fan , Yingying Jiang , Zhenhua Li , Lu Xu . Facile GSH responsive glycyrrhetinic acid conjunction for liver targeting therapy. Chinese Chemical Letters, 2025, 36(10): 110773-. doi: 10.1016/j.cclet.2024.110773
9. [9]
  Wei Yan , Naizhen Zhang , Xiao Liu , Qiyu He , Xucheng Lv , Jianghui Sun , Lili Zhuang , Yuexin Zou , Yajie Zhang , Yuhang Liang , Yanjie Wang , Siyuan Li , Yonghui Sun . Development of visible-light photocaged molecular glues (vc-MGs) for B-cell malignancies therapy with improved safety and pharmacokinetic profiles in vivo. Chinese Chemical Letters, 2026, 37(5): 112064-. doi: 10.1016/j.cclet.2025.112064
10. [10]
  Qiang Luo , Jinfeng Sun , Zhibo Li , Bin Liu , Jianxun Ding . Thermo-sensitive poly(amino acid) hydrogel mediates cytoprotection through an antioxidant mechanism. Chinese Chemical Letters, 2025, 36(7): 110433-. doi: 10.1016/j.cclet.2024.110433
11. [11]
  Qi Wei , Hua Xin , Xiaolong Wang , Changjuan Qin , Yuanzhen Su , Di Li , Jianxun Ding . Unimolecular chiral poly(amino acid)s as adjuvants of nanovaccines for augmented cancer immunotherapy. Chinese Chemical Letters, 2025, 36(11): 111477-. doi: 10.1016/j.cclet.2025.111477
12. [12]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
13. [13]
  Shaofeng Gong , Zi-Wei Deng , Chao Wu , Wei-Min He . Stabilized carbon radical-mediated three-component functionalization of amino acid/peptide derivatives. Chinese Chemical Letters, 2025, 36(5): 110936-. doi: 10.1016/j.cclet.2025.110936
14. [14]
  Jun Li , Shi-Hu Du , Yao Zhang , Jia Liu , Jing Chen , Shi-Bo Cheng . Shell-independent superhalogen formation in aluminum-based clusters via boron Lewis acid ligands functionalization. Chinese Chemical Letters, 2026, 37(1): 111177-. doi: 10.1016/j.cclet.2025.111177
15. [15]
  Zan Chen , Yi Wang , Yuxuan Zhou , Yunlang Li , Rong Xiong , Wenting Huang , Huanfeng Jiang , Wanqing Wu . Selective synthesis of [6-6-7]/[6-6-6] core polycyclic heterocycles via Lewis acid-mediated cascade annulation of 1,6-enynols with aminonitriles. Chinese Chemical Letters, 2026, 37(6): 111718-. doi: 10.1016/j.cclet.2025.111718
16. [16]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018
17. [17]
  Kebo Xie , Qian Zhang , Fei Ye , Jungui Dai . A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides. Chinese Chemical Letters, 2024, 35(6): 109028-. doi: 10.1016/j.cclet.2023.109028
18. [18]
  Tong Li , Leping Pan , Yan Zhang , Jihu Su , Kai Li , Kuiliang Li , Hu Chen , Qi Sun , Zhiyong Wang . Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp³)-H functionalization. Chinese Chemical Letters, 2024, 35(4): 108897-. doi: 10.1016/j.cclet.2023.108897
19. [19]
  Wei-Bin Li , Xiao-Chao Huang , Pei Liu , Jie Kong , Guo-Ping Yang . Recent advances in directing group assisted transition metal catalyzed para-selective C-H functionalization. Chinese Chemical Letters, 2025, 36(6): 110543-. doi: 10.1016/j.cclet.2024.110543
20. [20]
  Jun Jiang , Hui Dai , Tao Tu . Two vicinal C(sp³)-F bonds functionalization of perfluoroalkyl halides (PFAHs). Chinese Chemical Letters, 2025, 36(7): 111054-. doi: 10.1016/j.cclet.2025.111054

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1682)
HTML views(41)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return