Citation: Li Minhao, Wang Zeming, Yang Jie, Wang Jiaxi. Advances in Monolithic Columns Technology in HPLC[J]. Chemistry, ;2019, 82(1): 18-26. shu

Advances in Monolithic Columns Technology in HPLC

School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130

Corresponding author: Wang Jiaxi, wangjiaxi@ebu.edu.cn
Received Date: 1 July 2018
Accepted Date: 25 September 2018

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As a new type of separating medium, high performance liquid chromatography (HPLC) monolithic columns have attracted considerable attention on account of its own characteristics, such as the simple preparation process, easy to be modified and excellent separation properties. Especially, due to its favorable biocompatibility, high column efficiency, long life, wide of the raw material source, good repeatability, unrestricted by pH, polymer-based monolithic columns are frequently used to separate and detect some small molecules compounds and proteins in food, chemical industry, agriculture, environment and biomedical science, which have shown a promising application prospect. Refer to the latest reports about HPLC, this review will focus on the research achievements of the preparation, modification method and application of monolithic columns in recent ten years. In addition, the future prospects for development regarding monolithic columns in various fields are also expected.
- HPLC,
- Stationary phase,
- Polymeric monolith
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