Citation: Huan-Ping Xie, Bo Wu, Xin-Wei Wang, Yong-Gui Zhou. Chiral Brønsted acid-catalyzed conjugate addition of indoles to azadienes: Enantioselective synthesis of hetero-triarylmethanes[J]. Chinese Journal of Catalysis, ;2019, 40(10): 1566-1575. doi: S1872-2067(19)63396-6 shu

Chiral Brønsted acid-catalyzed conjugate addition of indoles to azadienes: Enantioselective synthesis of hetero-triarylmethanes

a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 27 June 2019
Revised Date: 20 July 2019

Fund Project: This work was supported by the National Natural Science Foundation of China (21532006), Dalian Bureau of Science and Technology (2016RD07), and the Strategic Priority Program of the Chinese Academy of Sciences (XDB17020300).

An efficient chiral Brønsted acid-catalyzed conjugate addition of indoles to azadienes has been successfully developed, which enables a facile approach to optically active hetero-triarylmethanes with excellent enantioselectivities and broad substrate scope. This chiral Brønsted acid catalytic system provides a new opportunity for the development of asymmetric reactions of azadienes.
- Conjugate addition,
- Hetero-triarylmethane,
- Azadiene,
- Indole,
- Chiral Brønsted acid
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