Citation: Zhu Yue, Zheng Dandan, Miao Heyi, Qian Cheng, Dai Hong, Liang Kai, Zhou Beibei, Shi Yujun, Xun Xiao, Wang Yang. Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety[J]. Chinese Journal of Organic Chemistry, ;2020, 40(12): 4315-4321. doi: 10.6023/cjoc202008031 shu

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Benzotriazolyl Moiety

College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Corresponding author: Dai Hong, daihong_2015@aliyun.com Wang Yang, wangyang1617@sina.com
Received Date: 18 August 2020
Revised Date: 27 September 2020
Available Online: 13 October 2020
Fund Project: the National Natural Science Foundation of China 21372135the Science and Technology Project Fund of Nantong City MS12019060Project supported by the National Natural Science Foundation of China (Nos. 21372135, 21802075), and the Science and Technology Project Fund of Nantong City (No. MS12019060)the National Natural Science Foundation of China 21802075

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In search of new N-heterocyclic compounds possessing good biological activities, 17 novel pyrazole oxime derivatives were designed and synthesized by introducing benzotriazole moiety into pyrazole oxime skeleton based on fenpyroximate. Their structures were tested by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data displayed that 3 compounds showed 70%~100% insecticidal activities towards Tetranychus cinnabarinus at 20 μg/mL. 6 compounds possessed 90%~100% mortality rates towards Aphis medicaginis at 20 μg/mL. Moreover, 16 compounds displayed more than 80% insecticidal activities against Mythimna separata (Walker) at 500 μg/mL.
- benzotriazole,
- pyrazole oxime,
- synthesis,
- biological activity
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