Citation: Wang Lingyun, Xin Shuqi, Tang Hao, Cao Derong. Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents[J]. Chinese Journal of Organic Chemistry, ;2020, 40(12): 4155-4167. doi: 10.6023/cjoc202005041 shu

Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640

Corresponding author: Wang Lingyun, lingyun@scut.edu.cn
Received Date: 18 May 2020
Revised Date: 17 June 2020
Available Online: 8 July 2020
Fund Project: the China Scholarship Council 201906155012the National Natural Science Foundation of China 22071065the Natural Science Foundation of Guangdong Province 2018B030311008Project supported by the National Natural Science Foundation of China (Nos. 21772045, 22071065), the Natural Science Foundation of Guangdong Province (No. 2018B030311008), the China Scholarship Council (No. 201906155012) and the Technology Program of Guangzhou City (No. 201904010414)the Technology Program of Guangzhou City 201904010414the National Natural Science Foundation of China 21772045

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Cancer has become one of the major threats to human health in modern society. Phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT), as a new type of tumor treatment, has received more and more attentions due to its high spatiotemporal precision, noninvasive nature, controllability, low toxicity and repeatable treatment without initial resistance. It is important to obtain a highly efficient and ideal photosensitizer for reactive oxygen species (ROS) generation for PDT. Photothermal agents with high photothermal conversion efficiency are also in urgent need for PTT. Diketopyrrolopyrrole (DPP) is an excellent type of photosensitizer and photothermal reagent because of its good structural planarity, strong electron affinity, simple synthesis, easy structure modification and high molar absorption coefficient. The research progress of DPP-based photosensitizers and photothermal agents in recent year, including structural modification of DPP, the structure-activity relationship, the mechanism of phototherapy and some representative examples is summarized. Finally, a perspective on the future development of phototherapy based on DPP is presented.
- diketopyrrolopyrrole,
- photodynamic therapy,
- photothermal therapy,
- combined therapy
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