Citation: Qin Wenbing, Chen Jiayi, Xiong Wei, Liu Guokai. Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3177-3195. doi: 10.6023/cjoc202005016 shu

Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents

School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, Guangdong 518060

Corresponding author: Liu Guokai, gkliu@szu.edu.cn
Received Date: 7 May 2020
Revised Date: 10 June 2020
Available Online: 24 June 2020
Fund Project: Natural Science Foundation of Guangdong Province 2020A1515010874Natural Science Foundation of Shenzhen City KQJSCX20180328095508144Project supported by the Natural Science Foundation of Shenzhen City (Nos. KQJSCX20180328095508144) and the Natural Science Foundation of Guangdong Province (No. 2020A1515010874)

Figures(44)

In the past two decades, the development and application of bench-stable electrophilic difluoromethylating reagents have attracted considerable attention. Consequently, some progress in this area has been ongoing recently. Electrophilic difluoromethylating reagents play a very important role in the synthesis of fluorine-containing compounds, due to their capability of readily transferring difluoromethyl moiety (CF₂H) into wide range of nucleophiles, as well as being used as difluoromethyl radical(•CF₂H) precursorfor radical difluoromethylations. However, the electrophilic difluoromethylating reagents and application therein remain still underdeveloped in comparison with nucleophilic ones. The research advance in electrophilic difluoromethylating reagents in past two decades is reviewed.
1. [1]
  (a) Smart, B. E. Chem. Rev. 1996, 96, 1555.
  (b) Jeschke, P.; Baston, E.; Leroux, F. R. Mini-Rev. Med. Chem. 2007, 7, 1027 and references therein.
  (c) Hagmann, W. K. J. Med. Chem. 2008, 51, 4359.
  (d) Wang, J.; Sánchez-Roselló, M.; Aceña, J. L.; del Pozo, C.; Sorochinsky, A. E.; Fustero, S.; Soloshonok, V. A.; Liu, H. Chem. Rev. 2014, 114, 2432.
  (e) Bassetto, M.; Ferla, S.; Pertusati, F. Future Med. Chem. 2015, 7, 527.
2. [2]
  (a) Goure, W. F.; Leschinsky, K. L.; Wratten, S. J.; Chupp, J. P. J. Agric. Food Chem. 1991, 39, 981.
  (b) Pérez, R. A.; Sánchez-Brunete, C.; Miguel, E.; Tadeo, J. L. J. Agric. Food Chem. 1998, 46, 1864.
  (c) Kirsch, P. Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications, 2nd ed., Wiley-VCH, Weinheim, 2013.
3. [3]
  (a) Kirsch, P.; Bremer, B. Angew. Chem., Int. Ed. 2000, 39, 4216.
  (b) Tasaka, T.; Takenaka, S.; Kabu, K.; Morita, Y.; Okamoto, H. Ferroelectronics 2002, 276, 83.
  (c) Boltalina, O. V.; Nakajima, T. New Fluorinated Carbons: Fundamentals and Applications, Elsevier, Amsterdam, 2016.
4. [4]
  (a) Bégué, J. P.; Bonnet-Delpon, D. Bioorganic and Medicinal Chemistry of Fluorine, Wiley-VCH, Weinheim, 2008.
  (b) Ojima, I. Fluorine in Medicinal Chemistry and Chemical Biology, Wiley-Blackwell, Chichester, 2009.
  (c) Gouverneur, V.; Muller, K. Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical Aspects to Clinical Applications, Imperial College Press, London, 2012.
5. [5]
6. [6]
7. [7]
  (a) Prakash, G. K. S.; Mandal, M.; Schweizer, S.; Petasis, N. A.; Olah, G. A. J. Org. Chem. 2002, 67, 3718.
  (b) Narjes, F.; Koehler, K. F.; Koch, U.; Gerlach, B.; Colarusso, S.; Steinkhler, C.; Brunetti, M.; Altamura, S.; De Francesco, R.; Matassa, V. G. Bioorg. Med. Chem. Lett. 2002, 12, 701.
  (c) Hu, J.; Zhang, W.; Wang. F. Chem. Commun. 2009, 7465.
8. [8]
  (a) Li, Y.; Hu, J. Angew. Chem., Int. Ed. 2005, 44, 5882.
  (b) Prakash, G. K. S.; Weber, C.; Chacko, S.; Olah, G. A. Org. Lett. 2007, 9, 1863.
9. [9]
  (a) Cazzola, M.; Picciolo, S.; Matera, M. G. Expert Opin. Pharmacother. 2010, 11, 441.
  (b) Kohl, B.; Sturm, E.; Rainer, G. US 4758579A, 1985.
  (c) Gajjar, D. A.; Bello, A.; Ge, Z.; Christopher, L.; Grasela, D. M. Antimicrob. Agents Chemother. 2003, 47, 2256.
  (d) Kastron, V. V.; Vitolin, R. O.; Fialkov, J. A.; Shelyazhenko, S. V. US 4219653, 1980.
10. [10]
11. [11]
  Umemoto, T. Chem. Rev. 1996, 96, 1757. doi: 10.1021/cr941149u
12. [12]
  (a) Yagupol'skii, L. M.; Kondratenko, N. Y.; Timofeeva, G. N. Zh. Org. Khim. 1984, 20, 115.
  (b) Umemoto, T.; Ishihara, S. J. Am. Chem. Soc. 1993, 115, 2156.
  (c) Umemoto, T.; Ishihara, S.; Adachi, K. J. Fluorine Chem. 1995, 74, 77.
  (d) Umemoto, T.; Ishihara, S. J. Fluorine Chem. 1999, 98, 75.
  (e) Umemoto, T.; Adachi, K. J. Org. Chem. 1994, 59, 5692.
  (f) Yang, J. J.; Kirchmeier, R. L.; Shreeve, J. M. J. Org. Chem. 1998, 63, 2656.
  (g) Ma, J.-A.; Cahard, D. J. Org. Chem. 2003, 68, 8726.
13. [13]
  (a) Prakash, G. K. S.; Weber, C.; Chacko, S.; Olah, G. A. Org. Lett. 2007, 9, 1863.
  (b) Prakash, G. K. S.; Weber, C.; Chacko, S.; Olah, G. A. J. Comb. Chem. 2007, 9, 920.
14. [14]
  Yue, C.-B.; Lin, J.-H.; Cai, J.; Zhang, C.-P.; Zhao, G.; Xiao, J.-C.; Li, H. RSC Adv. 2016, 6, 35705. doi: 10.1039/C6RA06338A
15. [15]
  (a) Noto, N.; Koike, T.; Akita, M. Chem. Sci. 2017, 8, 6375.
  (b) Noto, N.; Tanaka, Y.; Koike, T.; Akita, M. ACS Catal. 2018, 8, 9408.
16. [16]
  (a) Tang, X.-J.; Thomoson, C. S.; Dolbier, W. R. Jr. Org. Lett. 2014, 16, 4594.
  (b) Zhang, Z.; Tang, X.-J.; Thomoson, C. S.; Dolbier, W. R. Jr. Org. Lett. 2015, 17, 3528.
  (c) Zhang, Z.; Tang, X.-J.; Dolbier, W. R. Jr. Org. Lett. 2015, 17, 4401.
  (d) Rong, J.; Deng, L.; Tan, P.; Ni, C.; Gu, Y.; Hu, J. Angew. Chem., Int. Ed. 2016, 55, 2743.
  (e) Fu, W.; Han, X.; Zhu, M.; Xu, C.; Wang, Z.; Ji, B.; Hao, X.-Q.; Song, M.-P. Chem. Commun. 2016, 52, 13413.
  (f) Zhang, Z.; Tang, X.-J.; Dolbier, W. R. Jr. Org. Lett. 2016, 18, 1048.
  (g) Miao, W.; Zhao, Y.; Ni, C.; Gao, B.; Zhang, W.; Hu, J. J. Am. Chem. Soc. 2018, 140, 880.
  (h) Zhang, Z.; Martinez, H.; Dolbier, W. R. J. Org. Chem. 2017, 82, 2589.
  (i) Zhu, M.; Fu, W.; Wang, Z.; Xu, C.; Ji, B. Org. Biomol. Chem. 2017, 15, 9057.
  (j) Duchemin, N.; Buccafusca, R.; Daumas, M.; Ferey, V.; Arseniyadis, S. Org. Lett. 2019, 21, 8205.
  (k) Wang, Z.-S.; Chen, Y.-B.; Zhang, H.-W.; Sun, Z.; Zhu, C.; Ye, L. J. Am. Chem. Soc. 2020, 142, 3636.
17. [17]
  (a) Lu, S.-L.; Li, X.; Qin, W.-B.; Liu, J.-J.; Huang, Y.-Y.; Wong, H. N. C.; Liu, G.-K. Org. Lett. 2018, 20, 6925.
  (b) Liu, G.-K.; Li, X.; Qin, W.-B.; Peng, X.-S.; Wong, H. N. C.; Zhang, L.; Zhang, X. Chem. Commun. 2019, 55, 7446.
  (c) Liu, G.-K.; Qin, W.-B.; Li, X.; Lin, L.-T.; Wong, H. N. C. J. Org. Chem. 2019, 84, 15948.
  (d) Liu, G.-K.; Li, X.; Qin, W.-B.; Lin, W.-F.; Lin, L.-T.; Chen, J.-Y.; Liu, J.-J. Chin. Chem. Lett. 2019, 30, 1515.
18. [18]
  (a) Zhang, C.; Cao, H.; Wang, Z.; Zhang, C.; Chen, Q.; Xiao, J. Synlett 2010, 1089.
  (b) Liu, G.; Mori, S.; Wang, X.; Noritake, S.; Tokunaga, E.; Shibata, N. New J. Chem. 2012, 36, 1769.
  (c) Liu, G.; Wang, X.; Lu, X.; Xu, X.-H.; Tokunaga, E.; Shibata, N. ChemistryOpen 2012, 1, 227.
  (d) Liu, G.; Wang, X.; Xu, X.-H.; Lu, X.; Tokunaga, E.; Tsuzuki, S.; Shibata, N. Org. Lett. 2013, 15, 1044.
19. [19]
  (a) Zhang, W.; Wang, F.; Hu, J. Org. Lett. 2009, 11, 2109.
  (b) Pégot, B.; Urban, C.; Bourne, A.; Le, T. N.; Bouvet, S.; Marrot, J.; Diter, P.; Magnier, E. Eur. J. Org. Chem. 2015, 3069.
20. [20]
  (a) Prakash, G. K. S.; Zhang, Z.; Wang, F.; Ni, C.; Olah, G. A. J. Fluorine Chem. 2011, 132, 792.
  (b) Yang, Y.; Lu, X.; Liu, G.; Tokunaga, E.; Tsuzuki, S.; Shibata, N. ChemistryOpen 2012, 1, 221.
21. [21]
  (a) Arai, Y.; Tomita, R.; Ando, G.; Koike, T.; Akita, M. Chem.-Eur. J. 2016, 22, 1262.
  (b) Noto, N.; Koike, T.; Akita, M. J. Org. Chem. 2016, 81, 7064.
  (c) Nakayama, Y.; Ando, G.; Abe, M.; Koike, T.; Akita, M. ACS Catal. 2019, 9, 6555.
22. [22]
  (a) Zhu, J.; Liu, Y.; Shen, Q. Angew. Chem., Int. Ed. 2016, 55, 9050.
  (b) Zhu, J.; Zheng, H.; Xue, X.-S.; Xiao, Y.; Liu, Y.; Shen, Q. Chin. J. Chem. 2018, 36, 1069.
23. [23]
  Zheng, J.; Cai, J.; Lin, J.-H.; Guo, Y.; Xiao, J.-C. Chem. Commun. 2013, 49, 7513. doi: 10.1039/c3cc44271c
24. [24]
  (a) Zheng, J.; Lin, J.-H.; Cai, J.; Xiao, J.-C. Chem.-Eur. J. 2013, 19, 15261.
  (b) Deng, X.-Y.; Lin, J.-H.; Zheng, J.; Xiao, J.-C. Chem. Commun. 2015, 51, 8805.
  (c) Liu, C.; Deng, X.-Y.; Zeng, X.-L.; Zhao, G.; Lin, J.-H.; Wang, H.; Xiao, J.-C. J. Fluorine Chem. 2016, 192, 27.
25. [25]
  Hua, M.-Q.; Wang, W.; Liu, W.-H.; Wang, T.; Zhang, Q.; Huang, Y.; Zhu, W.-H. J. Fluorine Chem. 2016, 181, 22. doi: 10.1016/j.jfluchem.2015.11.003
26. [26]
  Zheng, Q.-T.; Wei, Y.; Zheng, J.; Duan, Y.-Y.; Zhao, G.; Wang, Z.-B.; Lin, J.-H.; Zheng, X.; Xiao, J.-C. RSC Adv. 2016, 6, 82298. doi: 10.1039/C6RA20629H
27. [27]
  Deng, X.-Y.; Lin, J.-H.; Xiao, J.-C. J. Fluorine Chem. 2015, 179, 116. doi: 10.1016/j.jfluchem.2015.06.009
28. [28]
  Zheng, J.; Lin, J.-H.; Yu, L.-Y.; Wei, Y.; Zheng, X.; Xiao, J.-C. Org. Lett. 2015, 17, 6150. doi: 10.1021/acs.orglett.5b03159
29. [29]
  (a) Reger, D. L.; Dukes, M. D. J. Organomet. Chem. 1978, 153, 67.
  (b) Vougioukalakis, G. C.; Grubbs, R. H. Chem. Rev. 2010, 110, 1746.
30. [30]
  Feng, Z.; Min, Q.-Q.; Zhang, X. Org. Lett. 2016, 18, 44. doi: 10.1021/acs.orglett.5b03206
31. [31]
  Deng, X.-Y.; Lin, J.-H.; Xiao, J.-C. Org. Lett. 2016, 18, 4384. doi: 10.1021/acs.orglett.6b02141
32. [32]
  Fu, X.-P.; Xue, X.-S.; Zhang, X.-Y.; Xiao, Y.-L.; Zhang, S.; Guo, Y.-L.; Leng, X.; Houk, K. N.; Zhang, X. Nat. Chem. 2019, 11, 948. doi: 10.1038/s41557-019-0331-9
33. [33]
  (a) Zheng, J.; Lin, J.-H.; Deng, X.-Y.; Xiao, J.-C. Org. Lett. 2015, 17, 532.
  (b) Wei, Y.; Yu, L.; Lin, J.; Zheng, X.; Xiao, J. Chin. J. Chem. 2016, 34, 481.
34. [34]
  (a) Zheng, J.; Wang, L.; Lin, J.-H.; Xiao, J.-C.; Liang, S. H. Angew. Chem., Int. Ed. 2015, 54, 13236.
  (b) Zheng, J.; Cheng, R.; Lin, J.-H.; Yu, D.-H.; Ma, L.; Jia, L.; Zhang, L.; Wang, L.; Xiao, J.-C.; Liang, S. H. Angew. Chem., Int. Ed. 2017, 56, 3196.
  (c) Yu, J.; Lin, J.-H.; Xiao, J.-C. Angew. Chem., Int. Ed. 2017, 56, 16669.
  (d) Luo, J.-J.; Zhang, M.; Lin, J.-H.; Xiao, J.-C. J. Org. Chem. 2017, 82, 11206.
  (e) Chen, X.-L.; Zhou, S.-H.; Lin, J.-H.; Deng, Q.-H.; Xiao, J.-C. Chem. Commun. 2019, 55, 1410.
35. [35]
  (a) Lin, Q.-Y.; Xu, X.-H.; Zhang, K.; Qing, F.-L. Angew. Chem., Int. Ed. 2016, 55, 1479.
  (b) Ran, Y.; Lin, Q.-Y.; Xu, X.-H.; Qing, F.-L. J. Org. Chem. 2016, 81, 7001.
  (c) Lin, Q.-Y.; Ran, Y.; Xu, X.-H.; Qing, F.-L. Org. Lett. 2016, 18, 2419.
  (d) Hu, W.-Q.; Xu, X.-H.; Qing, F.-L. J. Fluorine Chem. 2018, 208, 73.
36. [36]
  Ran, Y.; Lin, Q.-Y.; Xu, X.-H.; Qing, F.-L. J. Org. Chem. 2017, 82, 7373. doi: 10.1021/acs.joc.7b01041
37. [37]
  Yu, J.; Lin, J.-H.; Cao, Y.-C.; Xiao, J.-C. Org. Chem. Front. 2019, 6, 3580. doi: 10.1039/C9QO00919A
38. [38]
  Zhang, M.; Lin, J.-H.; Xiao, J.-C. Angew. Chem., Int. Ed. 2019, 58, 6079. doi: 10.1002/anie.201900466
39. [39]
  (a) Urban, C.; Macé, Y.; Cadoret, F.; Blazejewski, J. C.; Magnier, E. Adv. Synth. Catal. 2010, 352, 2805.
  (b) Urban, C.; Cadoret, F.; Blazejewski, J. C.; Magnier, E. Eur. J. Org. Chem. 2011, 4862.
  (c) Macé, Y.; Magnier, E. Eur. J. Org. Chem. 2012, 2479.
40. [40]
  (a) Zhang, W.; Zhu, J.; Hu, J. Tetrahedron Lett. 2008, 49, 5006.
  (b) He, Z.; Luo, T.; Hu, M.; Cao, Y.; Hu, J. Angew. Chem., Int. Ed. 2012, 51, 3944.
  (c) He, Z.; Hu, M.; Luo, T.; Li, L.; Hu, J. Angew. Chem., Int. Ed. 2012, 51, 11545.
41. [41]
  Wang, X.; Liu, G.; Xu, X.-H.; Shibata, N.; Tokunaga, E.; Shibata, N. Angew. Chem., Int. Ed. 2014, 53, 1827. doi: 10.1002/anie.201309875
1. [1]
  Min LIU , Huapeng RUAN , Zhongtao FENG , Xue DONG , Haiyan CUI , Xinping WANG . Neutral boron-containing radical dimers. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 123-130. doi: 10.11862/CJIC.20240362
2. [2]
  Xiaoning TANG , Shu XIA , Jie LEI , Xingfu YANG , Qiuyang LUO , Junnan LIU , An XUE . Fluorine-doped MnO₂ with oxygen vacancy for stabilizing Zn-ion batteries. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1671-1678. doi: 10.11862/CJIC.20240149
3. [3]
  Tingting Yu , Si Chen , Lianglong Sun , Tongtong Shi , Kai Sun , Xin Wang . Comprehensive Experimental Design for the Photochemical Synthesis, Analysis, and Characterization of Difluoropyrroles. University Chemistry, 2024, 39(11): 196-203. doi: 10.3866/PKU.DXHX202401022
4. [4]
  Lei Shi . Nucleophilicity and Electrophilicity of Radicals. University Chemistry, 2024, 39(11): 131-135. doi: 10.3866/PKU.DXHX202402018
5. [5]
  Jiaqi AN , Yunle LIU , Jianxuan SHANG , Yan GUO , Ce LIU , Fanlong ZENG , Anyang LI , Wenyuan WANG . Reactivity of extremely bulky silylaminogermylene chloride and bonding analysis of a cubic tetragermylene. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1511-1518. doi: 10.11862/CJIC.20240072
6. [6]
  Weina Wang , Lixia Feng , Fengyi Liu , Wenliang Wang . Computational Chemistry Experiments in Facilitating the Study of Organic Reaction Mechanism: A Case Study of Electrophilic Addition of HCl to Asymmetric Alkenes. University Chemistry, 2025, 40(3): 206-214. doi: 10.12461/PKU.DXHX202407022
7. [7]
  Baohua LÜ , Yuzhen LI . Anisotropic photoresponse of two-dimensional layered α-In₂Se₃(2H) ferroelectric materials. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1911-1918. doi: 10.11862/CJIC.20240105
8. [8]
  Chengqian Mao , Yanghan Chen , Haotong Bai , Junru Huang , Junpeng Zhuang . Photodimerization of Styrylpyridinium Salt and Its Application in Silk Screen Printing. University Chemistry, 2024, 39(5): 354-362. doi: 10.3866/PKU.DXHX202312014
9. [9]
  Danqing Wu , Jiajun Liu , Tianyu Li , Dazhen Xu , Zhiwei Miao . Research Progress on the Simultaneous Construction of C—O and C—X Bonds via 1,2-Difunctionalization of Olefins through Radical Pathways. University Chemistry, 2024, 39(11): 146-157. doi: 10.12461/PKU.DXHX202403087
10. [10]
  Hong RAO , Yang HU , Yicong MA , Chunxin LÜ , Wei ZHONG , Lihua DU . Synthesis and in vitro anticancer activity of phenanthroline-functionalized nitrogen heterocyclic carbene homo- and heterobimetallic silver/gold complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2429-2437. doi: 10.11862/CJIC.20240275
11. [11]
  Tiantian MA , Sumei LI , Chengyu ZHANG , Lu XU , Yiyan BAI , Yunlong FU , Wenjuan JI , Haiying YANG . Methyl-functionalized Cd-based metal-organic framework for highly sensitive electrochemical sensing of dopamine. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 725-735. doi: 10.11862/CJIC.20230351
12. [12]
  .
  南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积
  . CCS Chemistry, 2025, 7(0): -.
13. [13]
  Wentao Lin , Wenfeng Wang , Yaofeng Yuan , Chunfa Xu . Concerted Nucleophilic Aromatic Substitution Reactions. University Chemistry, 2024, 39(6): 226-230. doi: 10.3866/PKU.DXHX202310095
14. [14]
  Yinuo Wang , Siran Wang , Yilong Zhao , Dazhen Xu . Selective Synthesis of Diarylmethyl Anilines and Triarylmethanes via Multicomponent Reactions: Introduce a Comprehensive Experiment of Organic Chemistry. University Chemistry, 2024, 39(8): 324-330. doi: 10.3866/PKU.DXHX202401063
15. [15]
  Cuicui Yang , Bo Shang , Xiaohua Chen , Weiquan Tian . Understanding the Wave-Particle Duality and Quantization of Confined Particles Starting from Classic Mechanics. University Chemistry, 2025, 40(3): 408-414. doi: 10.12461/PKU.DXHX202407066
16. [16]
  Shahua Huang , Xiaoming Guo , Lin Lin , Guangping Chang , Sheng Han , Zuxin Zhou . Application of “Integration of Industry and Education” in Engineering Chemistry: Improvement of the Pesticide Fipronil Production. University Chemistry, 2024, 39(3): 199-204. doi: 10.3866/PKU.DXHX202309064
17. [17]
  Xiaofeng Xia , Jielian Zhu . Innovative Comprehensive Experimental Design: Synthesis of 6-Fluoro-N-benzoyl Tetrahydroquinoline. University Chemistry, 2024, 39(10): 344-352. doi: 10.12461/PKU.DXHX202405063
18. [18]
  Shiyang He , Dandan Chu , Zhixin Pang , Yuhang Du , Jiayi Wang , Yuhong Chen , Yumeng Su , Jianhua Qin , Xiangrong Pan , Zhan Zhou , Jingguo Li , Lufang Ma , Chaoliang Tan . 铂单原子功能化的二维Al-TCPP金属-有机框架纳米片用于增强光动力抗菌治疗. Acta Physico-Chimica Sinica, 2025, 41(5): 100046-. doi: 10.1016/j.actphy.2025.100046
19. [19]
  Yang Chen , Peng Chen , Yuyang Song , Yuxue Jin , Song Wu . Application of Chemical Transformation Driven Impurity Separation in Experiments Teaching: A Novel Method for Purification of α-Fluorinated Mandelic Acid. University Chemistry, 2024, 39(6): 253-263. doi: 10.3866/PKU.DXHX202310077
20. [20]
  Zhongyan Cao , Shengnan Jin , Yuxia Wang , Yiyi Chen , Xianqiang Kong , Yuanqing Xu . Advances in Highly Selective Reactions Involving Phenol Derivatives as Aryl Radical Precursors. University Chemistry, 2025, 40(4): 245-252. doi: 10.12461/PKU.DXHX202405186

Get Citation

PDF

XML

Metrics

PDF Downloads(120)
Abstract views(3503)
HTML views(1055)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

Metrics

通讯作者: 陈斌, bchen63@163.com