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Citation: Qin Wenbing, Chen Jiayi, Xiong Wei, Liu Guokai. Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents[J]. Chinese Journal of Organic Chemistry, ;2020, 40(10): 3177-3195. doi: 10.6023/cjoc202005016 shu

Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents

  • School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, Guangdong 518060

  • Corresponding author: Liu Guokai, gkliu@szu.edu.cn
  • Received Date: 7 May 2020
    Revised Date: 10 June 2020
    Available Online: 24 June 2020

    Fund Project: Natural Science Foundation of Guangdong Province 2020A1515010874Natural Science Foundation of Shenzhen City KQJSCX20180328095508144Project supported by the Natural Science Foundation of Shenzhen City (Nos. KQJSCX20180328095508144) and the Natural Science Foundation of Guangdong Province (No. 2020A1515010874)

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  • In the past two decades, the development and application of bench-stable electrophilic difluoromethylating reagents have attracted considerable attention. Consequently, some progress in this area has been ongoing recently. Electrophilic difluoromethylating reagents play a very important role in the synthesis of fluorine-containing compounds, due to their capability of readily transferring difluoromethyl moiety (CF2H) into wide range of nucleophiles, as well as being used as difluoromethyl radical(•CF2H) precursorfor radical difluoromethylations. However, the electrophilic difluoromethylating reagents and application therein remain still underdeveloped in comparison with nucleophilic ones. The research advance in electrophilic difluoromethylating reagents in past two decades is reviewed.
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