Citation: Cheng Xiaohong, Li Shuang, Wang Jingyang, Li Wangnan. "Turn-On" Fluorescent Probe for Hypochlorite: Successful Bioimaging and Real Application in Tap Water[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 1941-1947. doi: 10.6023/cjoc202003034 shu

"Turn-On" Fluorescent Probe for Hypochlorite: Successful Bioimaging and Real Application in Tap Water

a.
Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, Hubei 441053
b.
Hubei Institute of Aerospace Chemical Technology, Xiangyang, Hubei 441003

Corresponding author: Cheng Xiaohong, chengxiaohong0807@126.com
Received Date: 13 March 2020
Revised Date: 12 April 2020
Available Online: 11 May 2020
Fund Project: the Natural Science Foundation of Hubei Province 2018CFB454Project supported by the Natural Science Foundation of Hubei Province (No. 2018CFB454), the Project of Hubei University of Arts and Science (No. XK2020042) and the Teachers' Scientific Ability Cultivation Foundation of Hubei University of Arts and Science (No. 2020kypyfy031)the Project of Hubei University of Arts and Science XK2020042the Teachers' Scientific Ability Cultivation Foundation of Hubei University of Arts and Science 2020kypyfy031

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Taking advantage of the special oxidation property of hypochlorite, two novel coumarin-type fluorescent probes C1 and C2 were synthesized for ClO^- detection. Both probes could detect ClO^- anions in aqueous solution efficiently with rapid switching-on fluorescent methods. Especially, probe C2 displayed dramatic enhancement in fluorescence emission spectra with the detection limit of 1.8×10^-7 mol/L. In addition to its high selectivity for ClO^- rather than other common anions and reactive oxygen species, C2 was successfully applied to the bioimaging in HeLa cells with 'turn-on' fluorescent methods. Moreover, probe C2 could be used for the analysis of ClO^- levels in tap water and potentially in environmental samples.
- fluorescent probe,
- hypochlorite,
- good solubility,
- bioimaging application
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