Citation: Zheng Kanghe, Zhou Bingwei, Jin Hongwei, Liu Yunkui. Bifunctional Phosphine Ligand-Enabled Gold(Ⅰ)-Catalyzed Efficient Synthesis of 1, 5-Benzodiazepines[J]. Chinese Journal of Organic Chemistry, ;2020, 40(8): 2520-2525. doi: 10.6023/cjoc202003024 shu

Bifunctional Phosphine Ligand-Enabled Gold(Ⅰ)-Catalyzed Efficient Synthesis of 1, 5-Benzodiazepines

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Liu Yunkui, ykuiliu@zjut.edu.cn
Received Date: 9 March 2020
Revised Date: 28 May 2020
Available Online: 8 June 2020
Fund Project: The Natural Science Foundation of Zhejiang Province LY20B020013Project supported by the National Natural Science Foundation of China (Nos. 21772176, 21372201), and the Natural Science Foundation of Zhejiang Province(No. LY20B020013)The National Natural Science Foundation of China 21372201The National Natural Science Foundation of China 21772176

Figures(2)

At room temperature, a bifunctional phosphine-gold(Ⅰ) catalyst was used to catalyze the nucleophilic addition/cyclization reaction of o-phenylenediamines with alkynes to generate 1, 5-benzodiazepines in one step. The reaction has the advantages of high atomic-economy, simple raw materials, convenient operation and mild reaction conditions.
- phthaline diamine,
- alkyne,
- bifunctional phosphine ligand,
- gold catalysis,
- 1, 5-benzodiazepine
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