Citation: Li Ruoxin, Han Rui, Gao Jinming. Synthesis of Key Intermediate of Cyathane Diterpenes[J]. Chinese Journal of Organic Chemistry, ;2020, 40(7): 2148-2152. doi: 10.6023/cjoc201912037 shu

Synthesis of Key Intermediate of Cyathane Diterpenes

Shanxi Key Laboratory of Natural Products Chemistry and Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling, Shaanxi 712100

Corresponding author: Gao Jinming, jinminggao@nwsuaf.edu.cn
Received Date: 25 December 2019
Revised Date: 9 April 2020
Available Online: 23 April 2020

Figures(3)

A synthetic plan of bicyclo[5/6] key intermediate of cyathane is reported. All the involved reactions, such as nucleophilic substitution reaction, radical ring-closing reaction, Johnson-Claisen rearrangement and Grignard addition, were optimized for higher yields. The procedure provides a simple and efficient method for the synthesis of bicyclo-key intermediate of cyathane. It is expected to have wide applications in the synthesis of cyathane.
- cyathane diterpenes,
- natural product,
- nucleophilic substitution,
- Claisen rearrangement
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Synthesis of Key Intermediate of Cyathane Diterpenes

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com