Citation: Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong. "On Water" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones[J]. Chinese Journal of Organic Chemistry, ;2020, 40(5): 1323-1330. doi: 10.6023/cjoc201910038 shu

"On Water" Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones

Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou, Jiangxi 341000

Corresponding author: Zhang Yong, yong_zhanggnnu@126.com
Received Date: 29 October 2019
Revised Date: 14 January 2020
Available Online: 14 February 2020
Fund Project: the Education Department of Jiangxi Province GJJ170835the Jiangxi Provincial Department of Science and Technology Fund 20144BAB2130003Project supported by the National Natural Science Foundation of China (No. 21562003), the Jiangxi Provincial Department of Science and Technology Fund (20192BAB213007 and 20144BAB2130003), and the Education Department of Jiangxi Province (No. GJJ170835)the Jiangxi Provincial Department of Science and Technology Fund 20192BAB213007the National Natural Science Foundation of China 21562003

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A green and efficient nucleophilic addition reaction of trifluoromethyl ketone with pyrazolone was developed under "on water" conditions, affording pyrazolone substituted tertiary trifluoromethyl alcohols in high yields. The advantages of being catalyst-free, column chromatography-free, environmentally benign and easy workup make it a promising method for preparation of a variety of pyrazolone substituted tertiary trifluoromethyl alcohols.
- "on water" reaction,
- nucleophilic addition,
- pyrazolone,
- trifluoromethyl ketone
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