Citation: Xu Xinming, Li Jiazhu, Wang Zuli. Recent Advances in Transition Metal-Free Sulfenylation of Indoles[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 886-898. doi: 10.6023/cjoc201910020 shu

Recent Advances in Transition Metal-Free Sulfenylation of Indoles

Xu Xinming ^a,, ,
Li Jiazhu ^a ,
Wang Zuli ^b

a.
College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005
b.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, Shandong 266109

Corresponding author: Xu Xinming, Xin_MingXu@163.com
Received Date: 16 October 2019
Revised Date: 28 November 2019
Available Online: 19 December 2019
Fund Project: the Young Scholars Research Fund of Yantai University HY19B06Project supported by the Young Scholars Research Fund of Yantai University (No. HY19B06)

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Recently, the direct sulfenylation of C——H bond for C——S formation under transition metal-free conditions has rapidly advanced and is employed for eco-friendly synthesis of sulfenylated natural or bioactive compounds with various sulfenylating reagents. In particular, the sulfenylation of indoles is considered to be the most important because it can lead to a new class of molecules displaying a broad spectrum of biological and pharmaceutical activities. The recent five-year progress in direct C——H bond sulfenylation of indoles under transition metal-free conditions is discussed and their mechanisms in detail are described.
- sulfenylation,
- indoles,
- transition metal-free,
- reaction mechanism,
- synthetic method
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