Citation: Xu Weigang, Huang Danfeng, Wang Kehu, Zhao Fangxia, Zhao Zhuanxia, Hu Yongqing, Su Yingpeng, Hu Yulai. Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones[J]. Chinese Journal of Organic Chemistry, ;2020, 40(4): 922-929. doi: 10.6023/cjoc201910011 shu

Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Hu Yulai, huyl@nwnu.edu.cn
Received Date: 11 October 2019
Revised Date: 10 December 2019
Available Online: 27 December 2019
Fund Project: the National Natural Science Foundation of China 21662030Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21861033)the National Natural Science Foundation of China 21861033

Figures(2)

The Lewis acid catalyzed 1, 2-addition reaction of trifluoromethylated acylhydrazones with trimethylsilyl cyanide was investigated, and a series of cyanohydrazide compounds containing trifluoromethyl group were afforded in high yield. The method could be easily operated in mild reaction conditions, which provides an efficient method for the synthesis of trifluoromethylated hydrazides with structural diversity.
- trifluoromethylated acylhydrazones,
- trimethylsilyl cyanide,
- acylhydrazides,
- hydrocyanation
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