Citation: Ma Ben, Wang Ganggang, Zhou Hongyan, Yang Jingya. Alkali Salt-Catalyzed Aza-Michael Addition of 1, 2, 4-Triazole to α, β-Unsaturated Ketones and Imides[J]. Chinese Journal of Organic Chemistry, ;2020, 40(1): 115-124. doi: 10.6023/cjoc201907050 shu

Alkali Salt-Catalyzed Aza-Michael Addition of 1, 2, 4-Triazole to α, β-Unsaturated Ketones and Imides

Ma Ben ^a,, ,
Wang Ganggang ^a ,
Zhou Hongyan ^a,b ,
Yang Jingya ^a,,

a.
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
b.
College of Science, Gansu Agricultural University, Lanzhou 730070

Corresponding author: Ma Ben, maben@nwnu.edu.cn Yang Jingya, yangjy@nwnu.edu.cn
Received Date: 29 July 2019
Revised Date: 26 August 2019
Available Online: 13 January 2019
Fund Project: the National Natural Science Foundation of China 21362034Project supported by the National Natural Science Foundation of China (No. 21362034)

Figures(4)

An alkali salt-catalyzed highly efficient aza-Michael addition of 1, 2, 4-triazole to α, β-unsaturated ketones and imides has been developed, giving the desired products in moderate to excellent yields. The salient features of this reaction involve readily available starting materials, good substrate scope, mild condition, high efficiency and ease of scale-up. The product can be transformed into corresponding γ-aminoalcohol.
- synthetic methods,
- Michael addition,
- enones,
- α, β-unsaturated imides,
- nitrogen heterocycles,
- 1, 2, 4-triazole
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