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Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis
- Corresponding author: Li Dongli, wyuchemldl@wyu.edu.cn Zhang Weimin, wmzhang@gdim.cn
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Citation:
Chen Shushuai, Liu Hongxin, Liu Zhaoming, Li Saini, Chen Yuchan, Li Haohua, Li Dongli, Zhang Weimin. Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis[J]. Chinese Journal of Organic Chemistry,
;2020, 40(1): 209-214.
doi:
10.6023/cjoc201907041
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Six polyketides were isolated from the fermentation broth of an endophytic fungus Trichoderma spirale A725 of the medicinal plant Morinda officinalis by silica gel, reversed phase silica column chromatography, sephadex LH-20 and high performance preparative liquid chromatography. Their structures were elucidated to be 6-hydroxy-4-isopropyl-1, 8-dimethyl-spiro[4.5]deca-1, 8-dien-7-one (1), 2-hydroxy-2, 5-dimethyl-7-oxo-5, 7-dihydro-2H-furo[3, 4-b]pyran-4-carboxylicacid (2), 3-ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (3), harzialactone A (4), 3-hydroxy-5-(4-hydroxybenzyl)dihydrofuran-2(3H)-one (5), and 4-acetyl-3-hydroxy-6-methyl-pyran-2-one (6) on the basis of extensive spectral analysis. Among them, compounds 1 and 2 were new compounds, and compound 3 was a new natural product. Moreover, the cytotoxicities of compounds 1~6 were evaluated against four cancer cell lines (Hep G-2, MCF-7, SF-268 and A549). However, none of them exhibited cytotoxic activity against the tested tumor cells.
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Keywords:
- Morinda officinalis,
- endophyte fungus,
- Trichoderma spirale,
- polyketide
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