Citation: Song Wen-Yue, Rao Xiaofeng, Bu Qingqing, Liu Ning. Carbazole-Bridged NCN-Pincer Palladium Complex Catalyzed Direct C-H Arylation Reaction of Azoles[J]. Chinese Journal of Organic Chemistry, ;2020, 40(2): 489-500. doi: 10.6023/cjoc201907035 shu

Carbazole-Bridged NCN-Pincer Palladium Complex Catalyzed Direct C-H Arylation Reaction of Azoles

a.
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, Xinjiang 832003
b.
Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518000

Corresponding author: Bu Qingqing, bqq880219@163.com Liu Ning, ningliu@shzu.edu.cn
Received Date: 24 July 2019
Revised Date: 16 September 2019
Available Online: 9 February 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. U1603103)Project supported by the National Natural Science Foundation of China No. U1603103

Figures(3)

A new type of pincer palladium complexes C1~C6 based on the strong donor strength of carbazoles skeleton were synthesized. The air-and moisture-stable complexes C1~C6 act as efficient catalysts for the direct arylation of azoles with (hetero)aryl bromides in good to excellent yields with broad substrate scope used KOAc as sole base under aerobic conditions. It was demonstrated that this developed protocol was the most catalytic system for the direct C-H bond arylation for thiazoles under relatively mild reaction conditions at a low catalyst loading of 0.5 mol%.
- carbazole ligand,
- palladium complex,
- direct arylation,
- aryl bromides,
- coupling reaction
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