Citation: Shi Wangyu, Xu Jiaqing, Mao Biming, Jia Hao, Huang Jiaxing, Guo Hongchao. [3+2] Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines: Synthesis of Sipropyrazole Compounds[J]. Chinese Journal of Organic Chemistry, ;2020, 40(3): 756-762. doi: 10.6023/cjoc201907030 shu

[3+2] Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines: Synthesis of Sipropyrazole Compounds

Department of Chemistry, College of Science, China Agricultural University, Beijing 100193

Corresponding author: Huang Jiaxing, hchguo@cau.edu.cn Guo Hongchao, 05084@cau.edu.cn
Received Date: 22 July 2019
Revised Date: 18 October 2019
Available Online: 1 November 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21572264)Project supported by the National Natural Science Foundation of China No.21572264

Figures(2)

The[3+2] cycloaddition of methylenedihydrobenzofurandiones and nitrilimines worked efficiently in CHCl₃ at room temperature in the presence of Et₃N, producing biologically interesting spirocyclic pyrazole derivatives in high yield (78%~94%) with excellent diastereoselectivity.
- cycloaddition,
- nitrilimine,
- spirocyclic compound,
- pyrazole
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