Citation: Lin Wei, Zhuang Cangwei, Hu Xiuxiu, Yang Fengli. Efficient Synthesis of Coumarin-Fused Pyrazolo[3, 4-b]pyridine Derivatives Catalyzed by Niobic Acid Modified with Phosphoric Acid under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, ;2020, 40(2): 408-416. doi: 10.6023/cjoc201907026 shu

Efficient Synthesis of Coumarin-Fused Pyrazolo[3, 4-b]pyridine Derivatives Catalyzed by Niobic Acid Modified with Phosphoric Acid under Microwave Irradiation

School of Chemistry and Environmental Engineering, Jiangsu Techology of University, Changzhou, Jiangsu 213001

Corresponding author: Lin Wei, linwei@jsut.edu.cn Yang Fengli, yangfengli1984@hotmail.com
Received Date: 19 July 2019
Revised Date: 25 August 2019
Available Online: 25 February 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21502074), the Qing Lan Project of Jiangsu Province and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. SJCX19_0766)the Qing Lan Project of Jiangsu Province and the Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX19_0766the National Natural Science Foundation of China 21502074

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Coumarin and pyrazolo[3, 4-b]pyridine are structurally essential elements in biologically active natural compounds and are extremely important in medicinal chemistry by serving as key pharmacophores in drug discovery. In this article, the efficient synthesis of coumarin-fused pyrazolo[3, 4-b]pyridine via three-component domino reaction of aldehydes, coumarin derivative and 5-aminopyrazole in one step catalyzed by niobic acid modified with phosphoric acid under microwave irradiation has been achieved. The one-pot procedure, eco-friendly catalyst and solvent as well as simple operation are the key features of this method. The structures of the products were identified by IR, NMR, and HRMS spectra.
- coumarin,
- pyrazolo[3, 4-b]pyridine,
- synthesis,
- niobic acid
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