Citation: Xie Chang, Ma Chen, Jia Xu, Zhang Xueqi, Wei Chao, Zhang Pingzhu, Li Xiaoliu. A Response Rate Matching Dual-Reactable Probe for Fluorescent Recognition of Hydrogen Sulfide[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3277-3282. doi: 10.6023/cjoc201905038 shu

A Response Rate Matching Dual-Reactable Probe for Fluorescent Recognition of Hydrogen Sulfide

Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei 071002

Corresponding author: Wei Chao, weichao@hbu.edu.cn Li Xiaoliu, lixl@hbu.cn
Received Date: 16 May 2019
Revised Date: 24 June 2019
Available Online: 17 November 2019
Fund Project: the Colleges and Universities Science Technology Research Project of Hebei Province QN2017015Project supported by the National Natural Science Foundation of China (No. 21778013), the Natural Science Foundation of Hebei Province (No. B2018201234), the Colleges and Universities Science Technology Research Project of Hebei Province (No. QN2017015), the Science Technology Research and Development Guidance Programme Project of Baoding City (No. 16zg031) and the Open Fund of Laboratory in Hebei University (Nos. sy201833, KYZJX18144)the National Natural Science Foundation of China 21778013the Natural Science Foundation of Hebei Province B2018201234the Open Fund of Laboratory in Hebei University sy20183the Science Technology Research and Development Guidance Programme Project of Baoding City 16zg031the Open Fund of Laboratory in Hebei University KYZJX18144

Figures(7)

A dual-reactable H₂S fluorescent probe was designed and synthesized by employing ortho-fluoro-substituted coumarin azide and 7-nitrobenzofurazan-piperazine as the H₂S reactive groups and the fluorescence quenching groups. The recognition behaviors of the probe to H₂S were investigated and the results showed that the probe exhibited high selectivity and sensitivity. The fluorescence off-on enhancement was ca. 3600-fold, and the detection limit was 4.0×10^-8 mol/L. The results of enzyme activity test indicated that the probe could be used for cystathionine β-synthase (CBS) activity detection and inhibitor screening. Furthermore, the probe was successfully applied for the imaging of H₂S in living cells.
- hydrogen sulfide,
- response rate,
- dual-reactable,
- fluorescent probe
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