Citation: Li Mingrui, Ding Qifeng, Li Boyang, Yu Yang, Huang He, Huang Fei. Progress in the Synthesis of 1, 2, 4-Triazines by Tandem Cyclization[J]. Chinese Journal of Organic Chemistry, ;2019, 39(10): 2713-2725. doi: 10.6023/cjoc201905036 shu

Progress in the Synthesis of 1, 2, 4-Triazines by Tandem Cyclization

Li Mingrui ^a ,
Ding Qifeng ^a ,
Li Boyang ^a ,
Yu Yang ^c ,
Huang He ^a,b ,
Huang Fei ^a,b,,

a.
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816
b.
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023
c.
School of Environmental and Engineering, Nanjing Tech University, Nanjing 211816

Corresponding author: Huang Fei, huangfei0208@yeah.net
Received Date: 14 May 2019
Revised Date: 3 June 2019
Available Online: 24 October 2019
Fund Project: the National Natural Science Foundation of China 21901124the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture XTE1850Project supported by the National Natural Science Foundation of China (No. 21901124), the Jiangsu University Natural Science Research Program (No. 19KJB150032), the China Postdoctoral Science Foundation (No. 2019M651809), the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (No. XTE1850) and the Postdoctoral Science Foundation of Anhui Province (No. 2018B252)the Jiangsu University Natural Science Research Program 19KJB150032the China Postdoctoral Science Foundation 2019M651809the Postdoctoral Science Foundation of Anhui Province 2018B252

Figures(25)

1, 2, 4-Triazine compounds are an important class of nitrogen-containing heterocyclic compounds. They have wide applications in the fields of medicine, chemicals and materials. Therefore, green and highly efficient synthesis of 1, 2, 4-triazine compounds is increasingly attracting the attention of researchers. By tandem cyclization reaction, the post-treatment of intermediate is avoided, and the one-pot synthesis of triazine compounds is the most efficient and direct synthesis method, which conforms to the concept of green chemistry for its step and atomic economy. The formation of C-N bond based on tandem cyclization to give 1, 2, 4-triazine compounds is reviewed. The synthetic method, reaction mechanism and application of 1, 2, 4-triazine compounds are introduced under transition-metal and metal-free conditions in the past ten years. The prospects of synthesis of triazine rings are also discussed.
- 1, 2, 4-triazine,
- tandem cyclization,
- C-N bond formation,
- transition-metal catalysis,
- metal-free catalysis
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