Citation: Chen Xiaopei, Ma Zhiwei, Wang Chuanchuan, Liu Juntao, Wu Jinsong. Palladium-Catalyzed Regioselective ortho-Acylation of Azoxybenzenes under Aqueous Conditions[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3176-3182. doi: 10.6023/cjoc201905017 shu

Palladium-Catalyzed Regioselective ortho-Acylation of Azoxybenzenes under Aqueous Conditions

Faculty of Science, Henan University of Animal Husbandry and Economy, Zhengzhou 450046

Corresponding author: Chen Xiaopei, chenxp@hnuahe.edu.cn

^†

Received Date: 9 May 2019
Revised Date: 14 June 2019
Available Online: 9 November 2019
Fund Project: the Doctoral Research Startup Fund of Henan University of Animal Husbandry and Economy 53000168Project supported by the Key Scientific Research Project for Colleges and Universities of Henan Province (No. 20A150019) and the Doctoral Research Startup Fund of Henan University of Animal Husbandry and Economy (No. 53000168)the Key Scientific Research Project for Colleges and Universities of Henan Province 20A150019

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A facile and efficient protocol for palladium-catalyzed ortho-acylation of azoxybenzenes has been developed under aqueous conditions. In this process, the alcohols were oxidized into the corresponding aldehydes in situ, which coupled with azoxybenzenes with excellent regioselectivity, affording the acylated azoxybenzenes in moderate to good yields. A variety of functional groups were tolerated in this procedure.
- palladium catalysis,
- azoxybenzene,
- acylation,
- green chemistry
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