Citation: Dong Daoqing, Chen Wenjing, Chen Demao, Li Lixia, Li Guanghui, Wang Zuli, Deng Qi, Long Shu. Direct Synthesis of Sulfonated or Sulfenylated Pyrazolones Mediated by KIO₃ and Their Anti-microbial Activity[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3190-3198. doi: 10.6023/cjoc201904070 shu

Direct Synthesis of Sulfonated or Sulfenylated Pyrazolones Mediated by KIO₃ and Their Anti-microbial Activity

Dong Daoqing ^a,† ,
Chen Wenjing ^a,† ,
Chen Demao ^a ,
Li Lixia ^a ,
Li Guanghui ^a ,
Wang Zuli ^a,, ,
Deng Qi ^b ,
Long Shu ^c

a.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109
b.
School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201
c.
School of Chemistry and Food Engineering, Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology, Changsha 410114

Corresponding author: Wang Zuli, wangzulichem@163.com

^†

Received Date: 29 April 2019
Revised Date: 5 June 2019
Available Online: 2 November 2019
Fund Project: the National Natural Science Foundation of China 21772107the Research Fund of Qingdao Agricultural University's Highlevel Person 631303Project supported by the National Natural Science Foundation of China (Nos. 21402103, 21772107), the China Postdoctoral Science Foundation (No. 150030), and the Research Fund of Qingdao Agricultural University's Highlevel Person (No. 631303)the National Natural Science Foundation of China 21402103the China Postdoctoral Science Foundation 150030

Figures(2)

A facile and efficient method for the synthesis of sulfonated or sulfenylated pyrazolones catalyzed by KIO₃ was established. A variety of desired products were obtained in moderate to high yields. This methodology could be conducted under mild reaction conditions without requiring any metal. Control experiments showed that the mechanism of this reaction was different from previous KIO₃-catalyzed reactions. Some of these desired products showed high inhibitory activity against V. mali and B. cinerea.
- C-S bond,
- sulfonylation,
- sulfenylation,
- pyrazolones,
- iodine reagents,
- anti-microbial activity
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Direct Synthesis of Sulfonated or Sulfenylated Pyrazolones Mediated by KIO3 and Their Anti-microbial Activity

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Direct Synthesis of Sulfonated or Sulfenylated Pyrazolones Mediated by KIO₃ and Their Anti-microbial Activity