Citation: Wei Liang, Xiao Lu, Hu Yuanzheng, Wang Zuofei, Tao Haiyan, Wang Chunjiang. Recent Advances in Metallated Azomethine Ylides for the Synthesis of Chiral Unnatural α-Amino Acids[J]. Chinese Journal of Organic Chemistry, ;2019, 39(8): 2119-2130. doi: 10.6023/cjoc201904060 shu

Recent Advances in Metallated Azomethine Ylides for the Synthesis of Chiral Unnatural α-Amino Acids

Wei Liang ^a ,
Xiao Lu ^a ,
Hu Yuanzheng ^a ,
Wang Zuofei ^a ,
Tao Haiyan ^a ,
Wang Chunjiang ^a,b,,

a.
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
b.
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: Wang Chunjiang, cjwang@whu.edu.cn
Received Date: 24 April 2019
Revised Date: 25 May 2019
Available Online: 3 August 2019
Fund Project: Project supported by the National Natural Science Foundation of China 21772147Project supported by the National Natural Science Foundation of China 21525207the China Postdoctoral Science Foundation 2017M620331Project supported by the National Natural Science Foundation of China (Nos. 21525207, 21772147) and the China Postdoctoral Science Foundation (No. 2017M620331)

Figures(22)

The development of efficient methods for the preparation of unnatural amino acids has long been an important goal since their widely application in synthetic and medicinal chemistry. The asymmetric α-functionalization of nucleophilic metalated azomethine ylides, which could be in situ-generated from readily-available aldimine esters, has been recogonized as a powerful strategy to synthesize unnatural amino acids. Over the past 20 years, tranistion metal-catalyzed asymmetric construction of unnatural amino acids using azomethine ylides have been extensively studied. In this review, the progress on metallated azomethine ylides invovled aymmetric transformation for the synthesis of unnatural amino acids is summarized according to eletrophilic reagents.
- azomethine ylide,
- asymmetric catalysis,
- unnatural α-amino acid
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