Citation: Wang Xin, Mu Shiqiang, Sun Ting, Sun Kai. Eco-friendly C-3 Selenation of Imidazo[1, 2-a]pyridines in Ionic Liquid[J]. Chinese Journal of Organic Chemistry, ;2019, 39(10): 2802-2807. doi: 10.6023/cjoc201904057 shu

Eco-friendly C-3 Selenation of Imidazo[1, 2-a]pyridines in Ionic Liquid

College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000

Corresponding author: Wang Xin, wangx933@nenu.edu.cn Sun Kai, sunk468@nenu.edu.cn
Received Date: 24 April 2019
Revised Date: 12 June 2019
Available Online: 9 October 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21801007) and the Program for Innovative Research Team of Science and Technology in the University of Henan Province (Nos. 18IRTSTHN004, 18HASTIT006)the National Natural Science Foundation of China No.21801007the Program for Innovative Research Team of Science and Technology in the University of Henan Province 18HASTIT006the Program for Innovative Research Team of Science and Technology in the University of Henan Province 18IRTSTHN004

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An relative eco-friendly protocol for the direct C-3 selenation of imidazo[1, 2-a]pyridines with vorious organoselenides has been developed, gaving the desired products in moderate to excellent yields. Preliminary experimental results are consistent with a C-3 electrophilic functionalization mechanism. The features with relative green reaction conditions, broad substrate scope, and easy scale-up operation would make this strategy promising and important for the preparation of nitrogen and selenium containing molecules.
- selenation,
- imidazo[1, 2-a]pyridines,
- C-3 functionalization,
- electrophilic mechanism
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