Citation: Liu Tianbao, Peng Yanfen, Gui Meifang, Zhang Min. Metal-Free Rapid Synthesis of 2-Aroylamino Naphtho[1, 2-d]thiazoles[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3199-3206. doi: 10.6023/cjoc201904029 shu

Metal-Free Rapid Synthesis of 2-Aroylamino Naphtho[1, 2-d]thiazoles

Key Laboratory of Micro-nano Powder and Advanced Energy Materials of Anhui Higher Education Institutes, Department of Chemical and Material Engineering, Chizhou University, Chizhou, Anhui 247000

Corresponding author: Liu Tianbao, tianbaoliu1979@126.com Zhang Min, 287323206@qq.com
Received Date: 11 April 2019
Revised Date: 27 May 2019
Available Online: 2 November 2019
Fund Project: the Natural Science Foundation of Anhui Province 1808085QB48the National Natural Science Foundation of China 21271035the Provincial Teaching Team of Organic Chemistry 2017jxtd051Project supported by the National Natural Science Foundation of China (No. 21271035), the Natural Science Foundation of Anhui Province (No. 1808085QB48) and the Provincial Teaching Team of Organic Chemistry (No. 2017jxtd051)

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A novel and efficient approach has been developed to synthesize 2-aroylamino naphtho[1, 2-d]thiazole compounds through the reaction between 3-[1-(4-substituted naphthyl)]-1-aroylthiourea and iodosobenzene diacetate (IBD) under ambient air. A library of naphtho[1, 2-d]thiazole derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a metal-free synthesis, broad substrate scope, easily accessible reactants, excellent regioselectivity, room temperature reaction conditions under ambient air. The reported method is the efficient approach for the synthesis of naphtho[1, 2-d]thiazole derivatives.
- naphtho[1, 2-d]thiazole,
- thiourea,
- iodosobenzene diacetate,
- metal-free
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