Citation: Tang Hao, Luo Junfei, Xie Pan. Advances on the Synthesis of Aryl Ethers via Dehydrogenative Coupling[J]. Chinese Journal of Organic Chemistry, ;2019, 39(10): 2735-2743. doi: 10.6023/cjoc201904011 shu

Advances on the Synthesis of Aryl Ethers via Dehydrogenative Coupling

Tang Hao ^a ,
Luo Junfei ^a,, ,
Xie Pan ^b,,

a.
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211
b.
Shaanxi Key Laboratory of Chemistry Additives for Industry, College of Chemistry and Chemistry Engineering, Shaanxi University of Science & Technology, Xi'an 710021

Corresponding author: Luo Junfei, luojunfei@nbu.edu.cn Xie Pan, pan.xie@sust.edu.cn
Received Date: 4 April 2019
Revised Date: 9 May 2019
Available Online: 6 October 2019
Fund Project: the Education Foundation of Zhejiang Province Y201839228Project supported by the Natural Science Foundation of Zhejiang Province (No. LQ19B020002), the Municipal Natural Science Foundation of Ningbo City (No. 2018A610241), the Education Foundation of Zhejiang Province (No. Y201839228) and the K. C. Wong Magna Fund in Ningbo Universitythe Municipal Natural Science Foundation of Ningbo City 2018A610241the Natural Science Foundation of Zhejiang Province LQ19B020002

Figures(12)

Aryl ethers are important central motifs that are abundant in many natural products and drug molecules, as well as versatile building blocks for organic synthesis. Aryl ethers were usually synthesized through the coupling reactions between leaving group substituted arenes and alcohols. However, the introduction of leaving group requires extra synthetic operation and produces lots of wastes. Over the past decade, the method for the synthesis of aryl ethers via C-H alkoxylation or aryloxylation has received much attention due to its potential as an atom and step efficient methodology. Herein, the research advances on the synthesis of aryl ethers through dehydrogenative coupling are reviewed. The detailed substrate scopes and reaction mechanisms, as well as the limitations of current procedures and the prospects for the future, are discussed.
- aryl ether,
- dehydrogenative coupling,
- C-H activation,
- phenol,
- alcohol
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