Citation: Zhong Liangkun, Jiang Tao, Zhang Fan, Fu Qing, Liu Xinghai, Xu Tianming, Ding Chengrong, Chen Jie, Yuan Jing, Tan Chengxia. Synthesis and Insecticidal Activity of 3-Arylisoxazoline-pyrazole-5-carboxamide Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2655-2662. doi: 10.6023/cjoc201903056 shu

Synthesis and Insecticidal Activity of 3-Arylisoxazoline-pyrazole-5-carboxamide Derivatives

Zhong Liangkun ^a,b ,
Jiang Tao ^a ,
Zhang Fan ^b ,
Fu Qing ^a ,
Liu Xinghai ^a ,
Xu Tianming ^b ,
Ding Chengrong ^a ,
Chen Jie ^c ,
Yuan Jing ^c,, ,
Tan Chengxia ^a,,

a.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
b.
Zhejiang Research Institute of Chemical Industry. Ltd., Hangzhou 310023
c.
School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300

Corresponding author: Yuan Jing, 1015251265@qq.com Tan Chengxia, tanchengxia@zjut.edu.cn
Received Date: 26 March 2019
Revised Date: 19 April 2019
Available Online: 15 September 2019
Fund Project: the National Key Research and Development Plan 2017YFD0200507Project supported by the National Key Research and Development Plan (No. 2017YFD0200507)

Figures(3)

A series of 3-arylisoxazoline-pyrazole-5-carboxamide derivatives derived from ethyl 5, 5-dimethoxy-2, 4-dioxopentanoate were designed, synthesized, and characterized by ¹H NMR, ¹³C NMR and HRMS. The preliminary bioassay indicated that most title compounds exhibited positive potency against Mythimna separate (Walker) at 500 mg/L. At the concentration of 100 mg/L, three compounds were still moderately active against Mythimna separate (Walker) (lethal rate≈60%). At 500 mg/L, four compounds were also active against Aphis craccivora. The results indicated that the potential of these 3-arylisoxazoline-pyrazole-5-carboxamide derivatives can be utilized in insecticide research with further optimization.
- arylisoxazoline,
- pyrazole-5-carboxamide,
- synthesis,
- insecticidal activity
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