Citation: Li Shuailong, Li Zhuangxing, You Cai, Lv Hui, Zhang Xumu. Recent Advances in Asymmetric Hydroformylation[J]. Chinese Journal of Organic Chemistry, ;2019, 39(6): 1568-1582. doi: 10.6023/cjoc201903044 shu

Recent Advances in Asymmetric Hydroformylation

Li Shuailong ^a ,
Li Zhuangxing ^a ,
You Cai ^a ,
Lv Hui ^a,b,d,, ,
Zhang Xumu ^c

a.
Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
b.
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
c.
Department of Chemistry, Southern University of Science and Technology, Shenzhen Grubbs Institute, Shenzhen 518055
d.
Sauvage Center for Molecular Sciences, Wuhan University, Wuhan 430072

Corresponding author: Lv Hui, huilv@whu.edu.cn
Received Date: 22 March 2019
Revised Date: 23 April 2019
Available Online: 6 June 2019
Fund Project: the Natural Science Foundation of Hubei Province 2018CFB430Project supported by the National Natural Science Foundation of China (No. 21871212) and the Natural Science Foundation of Hubei Province (No. 2018CFB430)the National Natural Science Foundation of China 21871212

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Asymmetric hydroformylation is one of the most important reactions for preparation of chiral aldehydes from alkenes. Recently, significant progress has been made in this field and a series of new ligands have been developed. Asymmetric hydroformylation of several important alkenes has been achieved, offering efficient and concise methods for the synthesis of chiral aldehydes. In this review, the achievements of asymmetric hydroformylation of typical alkenes and the development of ligands for asymmetric hydroformylation are summarized.
- alkene,
- asymmetric hydroformylation,
- aldehyde,
- chiral phosphine ligand,
- rhodium
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