Citation: Liu Yiyi, Zhou Rong. Progress in Annulation Reactions Based on Huisgen Zwitterion[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2365-2378. doi: 10.6023/cjoc201903041 shu

Progress in Annulation Reactions Based on Huisgen Zwitterion

Liu Yiyi ^a,, ,
Zhou Rong ^b,,

a.
State Grid Hunan Electric Power Corporation Limited Research Institute, Changsha 410007
b.
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024

Corresponding author: Liu Yiyi, liuyy_chem@163.com Zhou Rong, zhourong@tyut.edu.cn
Received Date: 21 March 2019
Revised Date: 20 April 2019
Available Online: 6 September 2019
Fund Project: the National Natural Science Foundation of China (No. 21502135), the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province (No. 201802024)the National Natural Science Foundation of China 21502135the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province 201802024

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The development of highly efficient and selective synthetic methodologies is an important research task in organic chemistry. In recent years, the Huisgen zwitterions, a type of intermediates derived from nucleophilic addition of tertiary phosphine to azodicarboxylates, have shown unique superiority and efficiency in synthesis of azacyclic compounds, and therefore have attracted broad interest from organic chemists. A large number of annulation reactions based on Huisgen zwitterions have been reported. According to the types of electrophiles, the annulation reactions of Husigen zwitterions with carbonyl compounds, electron-deficient alkenes, imines, and other electrophiles are summarized, respectively.
- Huisgen zwitterion,
- tertiary phosphine,
- azodicarboxylate,
- azacyclic compounds,
- annulation reaction
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