Citation: Chang Yongxin, Li Bai, Guo Miao, Cai Yonghong, Xu Kuoxi. A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd²⁺ and Pyrophosphate Anion and Application in Cell Imaging[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2485-2491. doi: 10.6023/cjoc201903010 shu

A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd²⁺ and Pyrophosphate Anion and Application in Cell Imaging

Chang Yongxin ^a ,
Li Bai ^a ,
Guo Miao ^b ,
Cai Yonghong ^a,, ,
Xu Kuoxi ^a,,

a.
Engineering Laboratory for Flame Retardant and Functional Materials of Henan Province, Institute of Functional Organic Molecular Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004
b.
Institute of Nanomaterials Engineering Research Center, Henan University, Kaifeng 475004

Corresponding author: Cai Yonghong, caiyonghong@henu.edu.cn Xu Kuoxi, xukx@henu.edu.cn
Received Date: 5 March 2019
Revised Date: 18 March 2019
Available Online: 11 September 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. U1404207)the National Natural Science Foundation of China U1404207

Figures(11)

A novel fluorescent sensor L based on 8-hydroxyquinoline (8-HQ) has been designed and synthesized. The sensor L displayed excellent sensitivity specific toward Cd²⁺ and pyrophosphate anion (PPi), respectively. The fluorescence emission peak at 537 nm was quenched when Cd²⁺ was added to the DMSO/H₂O (V/V=1/1, 0.01 mol/L, Hepes-HCl buffer, pH=7.20) solution of sensor L and the detection limit was as low as 5.87×10^-8 mol/L. The 1:1 stoichiometry was verified by Job's plot and mass spectrum, and the association constant was obtained to be 4.37×10⁴ L/mol. The further study found that the L-Cd²⁺ system has high selectivity for detection of PPi by ligand replacement method and L could be used as a logic gate fluorescence sensor. In addition, the sensor L was employed for imaging the Cd²⁺ and PPi in living cells.
- 8-hydroxyquinoline,
- fluorescent sensor,
- sequential detection,
- cell imaging
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沈阳化工大学材料科学与工程学院沈阳 110142

A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd2+ and Pyrophosphate Anion and Application in Cell Imaging

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通讯作者: 陈斌, bchen63@163.com

A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd²⁺ and Pyrophosphate Anion and Application in Cell Imaging