Synthesis and Biological Activity Research of 4-Substitued-1-(2-methyl-6-(pyridin-3-yl)-nicotinoyl) Semicarbazides
- Corresponding author: Fang Meijuan, fangmj@xmu.edu.cn Zhao Shengxian, 2086488660@qq.com The authors contributed equally to this work
Citation:
Hu Hongyu, Wu Jun, Yuan Jianfeng, Wang Zhenni, Li Chenfan, Yan Xiaoyan, Fang Meijuan, Zhao Shengxian. Synthesis and Biological Activity Research of 4-Substitued-1-(2-methyl-6-(pyridin-3-yl)-nicotinoyl) Semicarbazides[J]. Chinese Journal of Organic Chemistry,
;2019, 39(9): 2507-2514.
doi:
10.6023/cjoc201902033
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Reagent and conditions: (ⅰ) ethyl acetoacetate, acetic acid, ammonium acetate, reflux, 5 h; (ⅱ) hydrazine hydrate, ethanol, reflux, 5 h (ⅲ) isocyanates, ethanol, 5 h