Citation: Yang Siqi, Li Xin, Peng Zhuojin, Yu Wenyan, Wang Guangxu, Jin Yalan, Zheng Bingbing, Dai Hongxue, Bai Dachang. Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates[J]. Chinese Journal of Organic Chemistry, ;2019, 39(6): 1623-1629. doi: 10.6023/cjoc201902025 shu

Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates

Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Corresponding author: Bai Dachang, baidachang@126.com
Received Date: 23 February 2019
Revised Date: 16 May 2019
Available Online: 28 June 2019
Fund Project: the Start-Up Fund from Henan Normal University qd17108the National Natural Science Foundation of China 21801067the Research Fund from Henan Normal University 5101034011009Project supported by the National Natural Science Foundation of China (No. 21801067), the Research Fund from Henan Normal University (No. 5101034011009), the Natural Science Research Program of Education Department of Henan Province (No. 18A150010), and the Start-Up Fund from Henan Normal University (No. qd17108)the Natural Science Research Program of Education Department of Henan Province 18A150010

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An improved method for the synthesis of pentafluoroethylated pyridines through Cu-catalyzed[3+3] cyclo-addition reaction of oxime acetates is reported. The starting materials are more readily available, and these reactions occurred under mild conditions with broad substrate scope and excellent regioselectivity. Mechanistic studies have also been preformed.
- pentafluoroethylated,
- pyridines,
- copper-catalyzed,
- oxime acetates
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