Citation: Li Xiaofang, Xiong Weikang, Ding Qiuping. Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 1867-1874. doi: 10.6023/cjoc201901029 shu

Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives

a.
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Nanchang 330022

Corresponding author: Ding Qiuping, dqpjxnu@gmail.com
Received Date: 19 January 2019
Revised Date: 17 February 2019
Available Online: 8 July 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21662017)the National Natural Science Foundation of China 21662017

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Phenylalanine derivatives are widely found in a broad range of pharmaceutical molecules and exhibit significant biological activity. Direct C-H bond functionalization of phenylalanine derivatives to offer an efficient approach to construct C-I, C(sp²)-C(sp²), C(sp²)-C(sp), C(sp²)-C(sp³), C-N, C-B and C-O bonds is described. The transformation involves ortho-C-H bond iodination and the following intramolecular amination, ortho-alkylation, ortho-arylation, ortho-alkenylation, ortho-alkynylation, ortho-acylation, ortho-acetoxylation, ortho-amination, ortho-boronation, meta-arylation and meta-alky-lation.
- phenylalanine,
- C-H functionalization,
- alkylation,
- alkenylation,
- arylation
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