Citation: Liu Jiaxin, Huang Danfeng, Wang Xiaoping, Zong Wuzhong, Su Yingpeng, Wang Kehu, Hu Yulai. Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides[J]. Chinese Journal of Organic Chemistry, ;2019, 39(6): 1767-1775. doi: 10.6023/cjoc201901007 shu

Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Huang Danfeng, huangdf@nwnu.edu.cn
Received Date: 7 January 2019
Revised Date: 29 January 2019
Available Online: 22 June 2019
Fund Project: the National Natural Science Foundation of China 21462037Project supported by the National Natural Science Foundation of China (Nos. 21861033, 21462037)the National Natural Science Foundation of China 21861033

Figures(3)

An efficient multicomponent one-pot reaction was developed for the synthesis of α-trifluoromethyl homoallylic hydrazides from the reactions of ethyl trifluoropyruvate, hydrazides and allylic bromide with tin powder in the presence of Brønsted and Lewis acid in 1, 4-dioxane under reflux. The method avoids the use of toxic stannanes and allows easy operation. The reaction proceeds smoothly under mild reaction conditions to give the corresponding products in good yields.
- one-pot,
- tin powder,
- ethyl trifluoropyruvate,
- α-trifluoromethyl homoallylic hydrazides
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