Citation: Feng Tong, Xue Zhongbo, Yin Juanjuan, Jiang Xu, Feng Yaqing, Meng Shuxian. Application of Fluoroboron Fluoresceins (BODIPYS) and Their Derivatives in the Synergistic Diagnosis and Treatment of Tumor[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 1891-1912. doi: 10.6023/cjoc201812016 shu

Application of Fluoroboron Fluoresceins (BODIPYS) and Their Derivatives in the Synergistic Diagnosis and Treatment of Tumor

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350

Corresponding author: Meng Shuxian, msxmail@tju.edu.cn
Received Date: 10 December 2018
Revised Date: 6 January 2019
Available Online: 19 July 2019
Fund Project: the China International Science and Technology Project 2012DFG41980the China International Science and Technology Project 2016YFE0114900Project supported by the National Natural Science Foundation of China (No. 21676187), and the China International Science and Technology Project (Nos. 2012DFG41980, 2016YFE0114900)the National Natural Science Foundation of China 21676187

Figures(35)

Tumor is one of the diseases with the highest mortality rate in the world. In view of the high risk and high mortality of tumor, researchers around the world are committed to develop more accurate and rapid diagnostic strategies and more effective treatments to fight tumor. Gradually, integrated optical diagnosis and treatment technologies for tumors have emerged. Fluoroboron fluorescein (BODIPY) has been widely used in tumor phototherapy because of its excellent optical properties. In this paper, BODIPY and its derivatives are introduced in detail as photosensitizers, photothermal transformants, and contrast agents in the diagnosis and treatment of tumors (photodynamic therapy, photothermal therapy, photoacoustic imaging) and integration of diagnosis and treatment. The effects of different BODIPY structures and their derivatives in tumor diagnosis and treatment were evaluated systematically. This is of great significance for the rational design of near-infrared BODIPY materials with high singlet oxygen quantum yield, high photothermal conversion, and good light stability and solubility.
- tumor,
- BODIPY,
- photodynamic therapy,
- photothermal therapy,
- photoacoustic imaging,
- synergistic theranostics
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