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Citation: Liu Hongxin, Li Haohua, Chen Yuchan, Tan Haibo, Zhang Weimin. Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola[J]. Chinese Journal of Organic Chemistry, ;2019, 39(5): 1475-1478. doi: 10.6023/cjoc201812009 shu

Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola

a.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070
b.
South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650

Corresponding author: Zhang Weimin, wmzhang@gdim.cn
Received Date: 6 December 2018
Revised Date: 9 January 2019
Available Online: 31 May 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080)the Guangdong Provincial Project for Science and Technology 2107A020211023the Pearl River Science and Technology New Star Fund of Guangzhou City 201806010080the National Natural Science Foundation of China 31600271

Figures(2)

The chemical investigation of the broth extract of the endophytic fungus Phomopsis phyllanthicola A658, which was isolated from the medicinal plant Pogostemon cablin, resulted in the isolation of one new compound, named dothiorelone O (1) and one new natural product 2-(3, 5-dihydroxy-2-(7-hydroxyoctanoyl)phenyl)acetic acid (2), along with four known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. Moreover, all of the compounds were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines.
- Pogostemon cablin,
- endophytic fungus,
- Phomopsis phyllanthicola,
- cytotoxicity
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