Citation: Zhu Jianrong, Ren Xiaojuan, Tang Feiyu, Pan Fei, Ye Longwu. Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides[J]. Chinese Journal of Organic Chemistry, ;2019, 39(4): 1102-1108. doi: 10.6023/cjoc201811007 shu

Synthesis of α-Halo Amides via Zinc-Mediated Tandem Oxidation/Halogenation of Ynamides

Zhu Jianrong ^a,, ,
Ren Xiaojuan ^a ,
Tang Feiyu ^a ,
Pan Fei ^b ,
Ye Longwu ^b,,

a.
Zhejiang Jingxin Pharmaceutical CO., LTD., Xinchang 312500
b.
College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Corresponding author: Zhu Jianrong, zhujianrong@jingxinpharm.com Ye Longwu, longwuye@xmu.edu.cn
Received Date: 5 November 2018
Revised Date: 29 November 2018
Available Online: 17 April 2018
Fund Project: the National Natural Science Foundation of China 21572186Project supported by the Key R&D Program of Zhejiang Province (No. 2017C03002) and the National Natural Science Foundation of China (No. 21572186)the Key R&D Program of Zhejiang Province 2017C03002

Figures(2)

α-Haloamides are a very important class of carbonyl compounds, and widely exist in a range of natural products and bioactive molecules. Herein, the realization of the tandem oxidation/halogenation of ynamides by employing the zinc halide as both the catalyst and the halogen source is described, thus avoiding the use of other external halogenating reagents. This method allows the practical synthesis of a variety of valuable α-haloamides in moderate to good yields.
- α-halo amides,
- oxidation,
- ynamide,
- tandem reaction
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