Citation: Zhang Yuping, Tian Xuechao, Zhang Yan, Hong Ran, Huang Shahua. Methods and Strategies for the Synthesis of Peduncularine[J]. Chinese Journal of Organic Chemistry, ;2019, 39(1): 47-58. doi: 10.6023/cjoc201810008 shu

Methods and Strategies for the Synthesis of Peduncularine

Zhang Yuping ^a ,
Tian Xuechao ^a ,
Zhang Yan ^b ,
Hong Ran ^b,, ,
Huang Shahua ^a,b,,

a.
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418
b.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Hong Ran, rhong@sioc.ac.cn Huang Shahua, shahua@sit.edu.cn
Received Date: 9 October 2018
Revised Date: 22 November 2018
Available Online: 5 January 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21402121) and the Collaborative Innovation Program of Shanghai Institute of Technology (No. XTCX2015-16)the Collaborative Innovation Program of Shanghai Institute of Technology XTCX2015-16Project supported by the National Natural Science Foundation of China 21402121

Figures(16)

(-)-Peduncularine is the principal alkaloid isolated from Tasmanian shrub Aristotelia peduncularis. Due to its unusual 6-azabicyclo[3.2.1]octane core, the indole alkaloid was received numerous attention from the synthetic community and several innovative synthetic strategies have been developed. In this minireview, the synthetic efforts of peduncularine are summarized as inspiration for future development of medicinally interesting derivatives.
- 6-azabicyclo[3.2.1]octane,
- cyclization,
- indole alkaloids,
- peduncularine,
- total synthesis
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