Citation: Zhang Cheng, Jiang Shichun, Chen Ying, Guo Tao, Xia Rongjiao, Tang Xu, Chen Lijuan, He Ming, Xue Wei. Synthesis and Biological of Novel Myricetin Derivatives Containing 1, 3, 4-Oxadiazoles[J]. Chinese Journal of Organic Chemistry, ;2019, 39(4): 1160-1168. doi: 10.6023/cjoc201809040 shu

Synthesis and Biological of Novel Myricetin Derivatives Containing 1, 3, 4-Oxadiazoles

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Corresponding author: Xue Wei, wxue@gzu.edu.cn
Received Date: 28 September 2018
Revised Date: 2 November 2018
Available Online: 17 April 2018
Fund Project: the National Key Research and Development Program of China 2017YFD0200506the National Natural Science Foundation of China 21867003Project supported by the National Key Research and Development Program of China (No.2017YFD0200506), and the National Natural Science Foundation of China (No.21867003)

Figures(4)

A series of novel myricetin derivatives containing 1, 3, 4-oxadiazole moiety were designed and synthesized.Bioassays indicated that some compounds showed potential antibacterial and antiviral activities. Among them, compounds 4a, 4b, 4f and 4j demonstrated appreciable inhibitory effect against Xanthomonas axonopodis pv.citri (Xac), with half-maximal effective concentration (EC₅₀) values of 18.5, 40.7, 26.9 and 32.4 μg/mL, which were significantly better than commercial agent bismerthiazol (68.8 μg/mL), compounds 4f and 4j also demonstrated appreciable inhibitory effect against Xanthomonas oryzae pv. Oryzae (Xoo) with EC₅₀ values of 45.9 and 35.7 μg/mL, which were better than commercial agent bismerthiazol (69.3 μg/mL). In addition, compounds 4n demonstrated significant curative activity against TMV with EC₅₀ value of 272.8 μg/mL, which was better than commercial agent ningnamycin (428.8 μg/mL), compounds 4f showed protecting activity against tobacco mosaic virus (TMV) with EC₅₀ value of 235.6 μg/mL, which was better than commercial agent ningnamycin (447.9 μg/mL). Microscale thermophoresis (MST) indicated that compound 4j could bind with south rice black drawf virus P9-1.
- myricetin,
- oxadiazole,
- biological activity,
- protein
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