Citation: Sheng Qiwei, Zhao Wanqiu, Zeng Ming, Xie Zhongpao, Xia Yaping, Cui Dongmei. Synthesis and Evaluation of Chalcone Derivatives as Novel Anticancer Agents[J]. Chinese Journal of Organic Chemistry, ;2019, 39(3): 703-708. doi: 10.6023/cjoc201808037 shu

Synthesis and Evaluation of Chalcone Derivatives as Novel Anticancer Agents

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Cui Dongmei, cuidongmei@zjut.edu.cn
Received Date: 29 August 2018
Revised Date: 23 October 2018
Available Online: 25 March 2018

Figures(1)

Three series of chalcones bearing a piperidino, morpholino, and 1-methylpiperazino moiety were synthesized in two steps with the key step being Claisen-Schmidt condensation and tested for the activity against five cell lines, MCF-7 (human breast adenocarcinoma cell line), A549 (human lung adenocarcinoma epithelial cell line), HL-60 (human leukemia cell line), Hela (human cervical cancer cell line), and Bewo (human chorionic tumor cell line) by thiazolyl blue tetrazolium bromide (MTT) assay. Some chalcones exhibited good anticancer activity, and among them 4a, 4e, 4f, 4j, 4m, and 4o displayed the best anticancer activity for MCF-7 breast cancer cells, A549 lung cancer cells, and HL-60 leukemia cancer cells with IC₅₀ values below 10 μmol/L, respectively.
- chalcone,
- condensation,
- anticancer agents,
- MTT assay
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